BRD-K80431395_TRICIRIBINE_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

286 genes differentially expressed following the BRD-K80431395_TRICIRIBINE_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BAMBI BMP and activin membrane-bound inhibitor
BLVRB biliverdin reductase B
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDN7 claudin 7
COL9A2 collagen, type IX, alpha 2
CTBP2 C-terminal binding protein 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSG3 desmoglein 3
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FBLN2 fibulin 2
FBN2 fibrillin 2
FOSL2 FOS-like antigen 2
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
GTPBP2 GTP binding protein 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
INHBA inhibin, beta A
INHBB inhibin, beta B
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB4 integrin, beta 4
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
KRT81 keratin 81, type II
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARS methionyl-tRNA synthetase
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MKNK2 MAP kinase interacting serine/threonine kinase 2
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MVP major vault protein
MYO1D myosin ID
MYO6 myosin VI
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NEU1 sialidase 1 (lysosomal sialidase)
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPARD peroxisome proliferator-activated receptor delta
PPL periplakin
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS8 protease, serine, 8
PSAT1 phosphoserine aminotransferase 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
REXO2 RNA exonuclease 2
RGS16 regulator of G-protein signaling 16
RIOK3 RIO kinase 3
RRAGC Ras-related GTP binding C
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SERINC3 serine incorporator 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
STC2 stanniocalcin 2
STX3 syntaxin 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGIF1 TGFB-induced factor homeobox 1
THBS2 thrombospondin 2
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WARS tryptophanyl-tRNA synthetase
WASL Wiskott-Aldrich syndrome-like
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AK4 adenylate kinase 4
AKAP7 A kinase (PRKA) anchor protein 7
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CD14 CD14 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHL1 cell adhesion molecule L1-like
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
CYCS cytochrome c, somatic
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCK deoxycytidine kinase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EED embryonic ectoderm development
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB2 homeobox B2
HOXB6 homeobox B6
HSDL2 hydroxysteroid dehydrogenase like 2
ICMT isoprenylcysteine carboxyl methyltransferase
IGF1 insulin-like growth factor 1 (somatomedin C)
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
METRN meteorin, glial cell differentiation regulator
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG2 non-SMC condensin II complex, subunit G2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUSAP1 nucleolar and spindle associated protein 1
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBX3 pre-B-cell leukemia homeobox 3
PEG3 paternally expressed 3
PGAM1 phosphoglycerate mutase 1 (brain)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PTTG1 pituitary tumor-transforming 1
QDPR quinoid dihydropteridine reductase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPW1 selenoprotein W, 1
SHCBP1 SHC SH2-domain binding protein 1
SKP1 S-phase kinase-associated protein 1
SLBP stem-loop binding protein
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDL1 spindle apparatus coiled-coil protein 1
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TK1 thymidine kinase 1, soluble
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TYMS thymidylate synthetase
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VCAN versican
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein