BRD-K80431395_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K80431395_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADCK3 aarF domain containing kinase 3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BBX bobby sox homolog (Drosophila)
BCL6 B-cell CLL/lymphoma 6
CCNG2 cyclin G2
CD58 CD58 molecule
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CETN3 centrin, EF-hand protein, 3
CHI3L2 chitinase 3-like 2
CTSB cathepsin B
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EFS embryonal Fyn-associated substrate
FAM129A family with sequence similarity 129, member A
FAM134A family with sequence similarity 134, member A
FAM60A family with sequence similarity 60, member A
FAM63A family with sequence similarity 63, member A
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GABARAPL1 GABA(A) receptor-associated protein like 1
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
HBP1 HMG-box transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AE histone cluster 1, H2ae
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IGF1R insulin-like growth factor 1 receptor
JUND jun D proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
KRT6B keratin 6B, type II
KYNU kynureninase
METTL7A methyltransferase like 7A
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OSER1 oxidative stress responsive serine-rich 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDZK1IP1 PDZK1 interacting protein 1
PLIN2 perilipin 2
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
RNMT RNA (guanine-7-) methyltransferase
RPL37A ribosomal protein L37a
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
SYNM synemin, intermediate filament protein
TEX10 testis expressed 10
TGIF1 TGFB-induced factor homeobox 1
TM4SF1 transmembrane 4 L six family member 1
TRIB1 tribbles pseudokinase 1
VEGFA vascular endothelial growth factor A
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ASRGL1 asparaginase like 1
BCHE butyrylcholinesterase
CBS cystathionine-beta-synthase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFH complement factor H
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CP ceruloplasmin (ferroxidase)
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
DCN decorin
DHCR24 24-dehydrocholesterol reductase
EFNB2 ephrin-B2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGF9 fibroblast growth factor 9
FLG filaggrin
GJA1 gap junction protein, alpha 1, 43kDa
HABP2 hyaluronan binding protein 2
HAL histidine ammonia-lyase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KCTD12 potassium channel tetramerization domain containing 12
KNG1 kininogen 1
LEPR leptin receptor
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
MAN1A1 mannosidase, alpha, class 1A, member 1
MECOM MDS1 and EVI1 complex locus
MFAP5 microfibrillar associated protein 5
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MYO1B myosin IB
PON3 paraoxonase 3
PSAT1 phosphoserine aminotransferase 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC63 SEC63 homolog (S. cerevisiae)
SEPT11 septin 11
SOX11 SRY (sex determining region Y)-box 11
SRPX sushi-repeat containing protein, X-linked
SUMO3 small ubiquitin-like modifier 3
TAGLN transgelin
TFRC transferrin receptor
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TMEM47 transmembrane protein 47
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VNN1 vanin 1