BRD-K80348542_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

269 genes differentially expressed following the BRD-K80348542_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
AKAP17A A kinase (PRKA) anchor protein 17A
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BANK1 B-cell scaffold protein with ankyrin repeats 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL10 B-cell CLL/lymphoma 10
BCL3 B-cell CLL/lymphoma 3
BEX1 brain expressed, X-linked 1
CCNL1 cyclin L1
CDK17 cyclin-dependent kinase 17
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEP192 centrosomal protein 192kDa
CHIC2 cysteine-rich hydrophobic domain 2
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
COL14A1 collagen, type XIV, alpha 1
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMTF1 cyclin D binding myb-like transcription factor 1
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
ECD ecdysoneless homolog (Drosophila)
EGR1 early growth response 1
EGR3 early growth response 3
ELF1 E74-like factor 1 (ets domain transcription factor)
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM179B family with sequence similarity 179, member B
FHL2 four and a half LIM domains 2
FNBP4 formin binding protein 4
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GOLGA8A golgin A8 family, member A
GSE1 Gse1 coiled-coil protein
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2B general transcription factor IIB
GTPBP8 GTP-binding protein 8 (putative)
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI44 interferon-induced protein 44
IFRD1 interferon-related developmental regulator 1
IL6 interleukin 6
ING3 inhibitor of growth family, member 3
INTS6 integrator complex subunit 6
IRF1 interferon regulatory factor 1
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JAM3 junctional adhesion molecule 3
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KDM6A lysine (K)-specific demethylase 6A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KYNU kynureninase
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIR22HG MIR22 host gene
MRPS31 mitochondrial ribosomal protein S31
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QKI QKI, KH domain containing, RNA binding
RBM26 RNA binding motif protein 26
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNMT RNA (guanine-7-) methyltransferase
RSRC2 arginine/serine-rich coiled-coil 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SP100 SP100 nuclear antigen
SRRM2 serine/arginine repetitive matrix 2
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
STAT1 signal transducer and activator of transcription 1, 91kDa
TERF2IP telomeric repeat binding factor 2, interacting protein
TESC tescalcin
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF4 transmembrane 4 L six family member 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNPO1 transportin 1
TRA2A transformer 2 alpha homolog (Drosophila)
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP3 ubiquitin specific peptidase 3
VEGFC vascular endothelial growth factor C
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
YTHDC1 YTH domain containing 1
ZBED5 zinc finger, BED-type containing 5
ZBTB20 zinc finger and BTB domain containing 20
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZNF24 zinc finger protein 24
ZNF274 zinc finger protein 274
ZNF410 zinc finger protein 410
ZNF432 zinc finger protein 432

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AHNAK2 AHNAK nucleoprotein 2
AIDA axin interactor, dorsalization associated
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
AKAP1 A kinase (PRKA) anchor protein 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AQP3 aquaporin 3 (Gill blood group)
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ATF5 activating transcription factor 5
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BCAP31 B-cell receptor-associated protein 31
C6ORF62 chromosome 6 open reading frame 62
C9ORF16 chromosome 9 open reading frame 16
CCNA2 cyclin A2
CCND2 cyclin D2
CD14 CD14 molecule
CD164 CD164 molecule, sialomucin
CD46 CD46 molecule, complement regulatory protein
CD58 CD58 molecule
CD99 CD99 molecule
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DEGS1 delta(4)-desaturase, sphingolipid 1
DHCR24 24-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
DTX4 deltex 4, E3 ubiquitin ligase
EFCAB14 EF-hand calcium binding domain 14
EMP2 epithelial membrane protein 2
ENO1 enolase 1, (alpha)
FABP1 fatty acid binding protein 1, liver
FAM134B family with sequence similarity 134, member B
FAM57A family with sequence similarity 57, member A
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
GCLM glutamate-cysteine ligase, modifier subunit
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
HMGB3 high mobility group box 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
INSIG1 insulin induced gene 1
IRAK1 interleukin-1 receptor-associated kinase 1
KAZN kazrin, periplakin interacting protein
KIAA0930 KIAA0930
KRT5 keratin 5, type II
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LHX2 LIM homeobox 2
MLEC malectin
MME membrane metallo-endopeptidase
MREG melanoregulin
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NMU neuromedin U
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEBP1 phosphatidylethanolamine binding protein 1
PERP PERP, TP53 apoptosis effector
PGK1 phosphoglycerate kinase 1
PI3 peptidase inhibitor 3, skin-derived
PODXL podocalyxin-like
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPT11 septin 11
SERINC5 serine incorporator 5
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SRSF1 serine/arginine-rich splicing factor 1
STEAP3 STEAP family member 3, metalloreductase
TFDP1 transcription factor Dp-1
TKT transketolase
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TMX1 thioredoxin-related transmembrane protein 1
TRIM14 tripartite motif containing 14
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXN thioredoxin
UBE3C ubiquitin protein ligase E3C
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WSB2 WD repeat and SOCS box containing 2
ZIC1 Zic family member 1