BRD-K80348542_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

272 genes differentially expressed following the BRD-K80348542_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
AKAP8L A kinase (PRKA) anchor protein 8-like
AMOTL2 angiomotin like 2
ANXA3 annexin A3
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOLD1 apolipoprotein L domain containing 1
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
CCL2 chemokine (C-C motif) ligand 2
CCNL1 cyclin L1
CDC7 cell division cycle 7
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CHIC2 cysteine-rich hydrophobic domain 2
CLK4 CDC-like kinase 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL13A1 collagen, type XIII, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMTF1 cyclin D binding myb-like transcription factor 1
DNMBP dynamin binding protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHA2 EPH receptor A2
ERBB4 erb-b2 receptor tyrosine kinase 4
EXOSC8 exosome component 8
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GOLGA8A golgin A8 family, member A
GPATCH8 G patch domain containing 8
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IFRD1 interferon-related developmental regulator 1
IL6 interleukin 6
ING3 inhibitor of growth family, member 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRF1 interferon regulatory factor 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LIPG lipase, endothelial
LMO3 LIM domain only 3 (rhombotin-like 2)
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAL mal, T-cell differentiation protein
MCM7 minichromosome maintenance complex component 7
MECOM MDS1 and EVI1 complex locus
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRG1 neuregulin 1
PALLD palladin, cytoskeletal associated protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP8 poly (ADP-ribose) polymerase family, member 8
PAX8 paired box 8
PAXBP1 PAX3 and PAX7 binding protein 1
PDLIM5 PDZ and LIM domain 5
PECAM1 platelet/endothelial cell adhesion molecule 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PILRB paired immunoglobin-like type 2 receptor beta
PLAU plasminogen activator, urokinase
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PPAP2B phosphatidic acid phosphatase type 2B
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PSPC1 paraspeckle component 1
PTPRM protein tyrosine phosphatase, receptor type, M
RAE1 ribonucleic acid export 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFC4 replication factor C (activator 1) 4, 37kDa
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RPP38 ribonuclease P/MRP 38kDa subunit
RSRC2 arginine/serine-rich coiled-coil 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SDC4 syndecan 4
SOX9 SRY (sex determining region Y)-box 9
SPG11 spastic paraplegia 11 (autosomal recessive)
SPINK1 serine peptidase inhibitor, Kazal type 1
SRRM2 serine/arginine repetitive matrix 2
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
STAT1 signal transducer and activator of transcription 1, 91kDa
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBX3 T-box 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS1 thrombospondin 1
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIK TRAF2 and NCK interacting kinase
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
U2SURP U2 snRNP-associated SURP domain containing
UBAP2 ubiquitin associated protein 2
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
UVRAG UV radiation resistance associated
VCPKMT valosin containing protein lysine (K) methyltransferase
WDR7 WD repeat domain 7
WEE1 WEE1 G2 checkpoint kinase
YTHDC1 YTH domain containing 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF24 zinc finger protein 24
ZNF451 zinc finger protein 451
ZNF767P zinc finger family member 767, pseudogene

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABR active BCR-related
ADD3 adducin 3 (gamma)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CALR calreticulin
CANT1 calcium activated nucleotidase 1
CAPNS1 calpain, small subunit 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCNG1 cyclin G1
CD58 CD58 molecule
CD99 CD99 molecule
CFH complement factor H
CNIH1 cornichon family AMPA receptor auxiliary protein 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CSTB cystatin B (stefin B)
CYBRD1 cytochrome b reductase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DBN1 drebrin 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNASE2 deoxyribonuclease II, lysosomal
DPYSL2 dihydropyrimidinase-like 2
ECI2 enoyl-CoA delta isomerase 2
EMP2 epithelial membrane protein 2
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EYA2 EYA transcriptional coactivator and phosphatase 2
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FKBP1A FK506 binding protein 1A, 12kDa
FOLR1 folate receptor 1 (adult)
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GSTA1 glutathione S-transferase alpha 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB3 high mobility group box 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LY6E lymphocyte antigen 6 complex, locus E
MAGED1 melanoma antigen family D1
MALL mal, T-cell differentiation protein-like
MAT2A methionine adenosyltransferase II, alpha
MDK midkine (neurite growth-promoting factor 2)
METTL9 methyltransferase like 9
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRN1 neuritin 1
OLFML3 olfactomedin-like 3
PAM peptidylglycine alpha-amidating monooxygenase
PGK1 phosphoglycerate kinase 1
PKM pyruvate kinase, muscle
PRDX4 peroxiredoxin 4
RABAC1 Rab acceptor 1 (prenylated)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOC ras homolog family member C
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A7 S100 calcium binding protein A7
SCAMP1 secretory carrier membrane protein 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SNN stannin
SPON2 spondin 2, extracellular matrix protein
SST somatostatin
TBC1D16 TBC1 domain family, member 16
TBCB tubulin folding cofactor B
TMEM14A transmembrane protein 14A
TMEM164 transmembrane protein 164
TPBG trophoblast glycoprotein
TPI1 triosephosphate isomerase 1
TPM4 tropomyosin 4
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WSB2 WD repeat and SOCS box containing 2