BRD-K80094086_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K80094086_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DES desmin
DGKA diacylglycerol kinase, alpha 80kDa
DHRS7 dehydrogenase/reductase (SDR family) member 7
DRAM1 DNA-damage regulated autophagy modulator 1
ECM1 extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8 epidermal growth factor receptor pathway substrate 8
F13A1 coagulation factor XIII, A1 polypeptide
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FHL1 four and a half LIM domains 1
FOXO4 forkhead box O4
FXYD5 FXYD domain containing ion transport regulator 5
GLRX glutaredoxin (thioltransferase)
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IL7R interleukin 7 receptor
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUN jun proto-oncogene
KRT19 keratin 19, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1B microtubule-associated protein 1B
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
MTMR11 myotubularin related protein 11
MX1 MX dynamin-like GTPase 1
NELL2 NEL-like 2 (chicken)
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PDLIM3 PDZ and LIM domain 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PON3 paraoxonase 3
PROCR protein C receptor, endothelial
PROM1 prominin 1
PYGL phosphorylase, glycogen, liver
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS10 regulator of G-protein signaling 10
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SYT1 synaptotagmin I
TCEA2 transcription elongation factor A (SII), 2
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TWF2 twinfilin actin binding protein 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AGTR1 angiotensin II receptor, type 1
EBNA1BP2 EBNA1 binding protein 2
FGFR3 fibroblast growth factor receptor 3
HACD2 3-hydroxyacyl-CoA dehydratase 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM3 intercellular adhesion molecule 3
ITGB1BP1 integrin beta 1 binding protein 1
KRT10 keratin 10, type I
LIG1 ligase I, DNA, ATP-dependent
MICALL1 MICAL-like 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PPIF peptidylprolyl isomerase F
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RRP1B ribosomal RNA processing 1B
SMC2 structural maintenance of chromosomes 2
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TOP2A topoisomerase (DNA) II alpha 170kDa