BRD-K79759585_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K79759585_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ANPEP alanyl (membrane) aminopeptidase
CA2 carbonic anhydrase II
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN8 claudin 8
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
LMNA lamin A/C
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NELL2 NEL-like 2 (chicken)
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM4 PDZ and LIM domain 4
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SESN1 sestrin 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BARD1 BRCA1 associated RING domain 1
BRCA1 breast cancer 1, early onset
CADM1 cell adhesion molecule 1
CCNE2 cyclin E2
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPU centromere protein U
CHEK2 checkpoint kinase 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
HADH hydroxyacyl-CoA dehydrogenase
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MBP myelin basic protein
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYH10 myosin, heavy chain 10, non-muscle
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RRM2 ribonucleotide reductase M2
SMC2 structural maintenance of chromosomes 2
SPC25 SPC25, NDC80 kinetochore complex component
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TXNDC9 thioredoxin domain containing 9
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
ZWINT ZW10 interacting kinetochore protein