BRD-K79554012_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K79554012_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADK adenosine kinase
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BZW1 basic leucine zipper and W2 domains 1
C14ORF132 chromosome 14 open reading frame 132
CCL20 chemokine (C-C motif) ligand 20
CCND3 cyclin D3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CGRRF1 cell growth regulator with ring finger domain 1
CLU clusterin
CORO1A coronin, actin binding protein, 1A
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP5 dual specificity phosphatase 5
EDNRB endothelin receptor type B
EIF4A3 eukaryotic translation initiation factor 4A3
FABP7 fatty acid binding protein 7, brain
FAR2 fatty acyl CoA reductase 2
FOXO4 forkhead box O4
GLRX glutaredoxin (thioltransferase)
GSTA4 glutathione S-transferase alpha 4
HEBP1 heme binding protein 1
HPCAL1 hippocalcin-like 1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGMN legumain
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
MSN moesin
MVP major vault protein
OPN3 opsin 3
PNMA2 paraneoplastic Ma antigen 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPCT glutaminyl-peptide cyclotransferase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SELL selectin L
SEPP1 selenoprotein P, plasma, 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STXBP1 syntaxin binding protein 1
SYBU syntabulin (syntaxin-interacting)
SYNE1 spectrin repeat containing, nuclear envelope 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TRAK2 trafficking protein, kinesin binding 2
TXNDC9 thioredoxin domain containing 9
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
ANPEP alanyl (membrane) aminopeptidase
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BID BH3 interacting domain death agonist
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CPE carboxypeptidase E
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP3 dual specificity phosphatase 3
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GABPB1 GA binding protein transcription factor, beta subunit 1
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H2BG histone cluster 1, H2bg
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KEAP1 kelch-like ECH-associated protein 1
LOX lysyl oxidase
NID1 nidogen 1
PDGFA platelet-derived growth factor alpha polypeptide
PLK2 polo-like kinase 2
RPL10 ribosomal protein L10
SDC1 syndecan 1
SENP6 SUMO1/sentrin specific peptidase 6
SFRP1 secreted frizzled-related protein 1
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SMYD2 SET and MYND domain containing 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TRIM13 tripartite motif containing 13
UBE2J1 ubiquitin-conjugating enzyme E2, J1
ZNF512B zinc finger protein 512B