BRD-K79511609_2-chloroadenosine_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K79511609_2-chloroadenosine_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL4 adhesion G protein-coupled receptor L4
AREG amphiregulin
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CD38 CD38 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
CYTIP cytohesin 1 interacting protein
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
EPHA4 EPH receptor A4
FGG fibrinogen gamma chain
GAGE3 G antigen 3
GBP1 guanylate binding protein 1, interferon-inducible
GMFG glia maturation factor, gamma
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
INHBA inhibin, beta A
KLF9 Kruppel-like factor 9
LAMP3 lysosomal-associated membrane protein 3
LRRC17 leucine rich repeat containing 17
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP3 TIMP metallopeptidase inhibitor 3
TRD T cell receptor delta locus
TRPS1 trichorhinophalangeal syndrome I
ZIC1 Zic family member 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACLY ATP citrate lyase
AKR1C3 aldo-keto reductase family 1, member C3
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BUB3 BUB3 mitotic checkpoint protein
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHERP calcium homeostasis endoplasmic reticulum protein
CRYZ crystallin, zeta (quinone reductase)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPYSL2 dihydropyrimidinase-like 2
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM98A family with sequence similarity 98, member A
FEN1 flap structure-specific endonuclease 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOSL1 FOS-like antigen 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAS1 growth arrest-specific 1
GMDS GDP-mannose 4,6-dehydratase
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP4 insulin-like growth factor binding protein 4
INTS5 integrator complex subunit 5
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KAT6B K(lysine) acetyltransferase 6B
KCTD12 potassium channel tetramerization domain containing 12
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LOXL1 lysyl oxidase-like 1
LTBP3 latent transforming growth factor beta binding protein 3
LTF lactotransferrin
MAP1B microtubule-associated protein 1B
MCM6 minichromosome maintenance complex component 6
MKI67 marker of proliferation Ki-67
MMP7 matrix metallopeptidase 7
MRPS30 mitochondrial ribosomal protein S30
MSH6 mutS homolog 6
NKX3-1 NK3 homeobox 1
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP85 nucleoporin 85kDa
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIP prolactin-induced protein
PKM pyruvate kinase, muscle
PRC1 protein regulator of cytokinesis 1
PRKCA protein kinase C, alpha
PUF60 poly-U binding splicing factor 60KDa
RAB8A RAB8A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBBP4 retinoblastoma binding protein 4
RRM2 ribonucleotide reductase M2
SFN stratifin
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SPDEF SAM pointed domain containing ETS transcription factor
SPTBN1 spectrin, beta, non-erythrocytic 1
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
TBC1D4 TBC1 domain family, member 4
TCERG1 transcription elongation regulator 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNC tenascin C
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
ZC3H13 zinc finger CCCH-type containing 13
ZCCHC24 zinc finger, CCHC domain containing 24