BRD-K79259477_KIN001-265_HEPG2_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K79259477_KIN001-265_HEPG2_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A1CF APOBEC1 complementation factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIM1 absent in melanoma 1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALDOB aldolase B, fructose-bisphosphate
APOE apolipoprotein E
AQP9 aquaporin 9
BASP1 brain abundant, membrane attached signal protein 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BLNK B-cell linker
BMP7 bone morphogenetic protein 7
C14ORF132 chromosome 14 open reading frame 132
C5 complement component 5
CCNG2 cyclin G2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES2 carboxylesterase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC3 chloride intracellular channel 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSTA cystatin A (stefin A)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM102A family with sequence similarity 102, member A
FAM63A family with sequence similarity 63, member A
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GSTA1 glutathione S-transferase alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAOB monoamine oxidase B
MME membrane metallo-endopeptidase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
PBLD phenazine biosynthesis-like protein domain containing
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM1 PDZ and LIM domain 1
PHGDH phosphoglycerate dehydrogenase
PNMA2 paraneoplastic Ma antigen 2
PSPH phosphoserine phosphatase
QPRT quinolinate phosphoribosyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPHS2 selenophosphate synthetase 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SESN1 sestrin 1
SIRT3 sirtuin 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STXBP1 syntaxin binding protein 1
TARP TCR gamma alternate reading frame protein
TGM1 transglutaminase 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TST thiosulfate sulfurtransferase (rhodanese)
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM9 ADAM metallopeptidase domain 9
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
BAG2 BCL2-associated athanogene 2
BCHE butyrylcholinesterase
BTG3 BTG family, member 3
C8ORF4 chromosome 8 open reading frame 4
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
EPCAM epithelial cell adhesion molecule
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM216A family with sequence similarity 216, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLRX glutaredoxin (thioltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HOPX HOP homeobox
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGHM immunoglobulin heavy constant mu
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LIF leukemia inhibitory factor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCAM melanoma cell adhesion molecule
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUP88 nucleoporin 88kDa
PAK1IP1 PAK1 interacting protein 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLN phospholamban
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLS1 plastin 1
RGS5 regulator of G-protein signaling 5
SCGB2A2 secretoglobin, family 2A, member 2
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC43A3 solute carrier family 43, member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX4 SRY (sex determining region Y)-box 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCF4 transcription factor 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCL1A T-cell leukemia/lymphoma 1A
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM243 transmembrane protein 243, mitochondrial
TSPAN13 tetraspanin 13
TXNDC9 thioredoxin domain containing 9
VCAN versican
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing