BRD-K79259477_KIN001-265_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K79259477_KIN001-265_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
AMACR alpha-methylacyl-CoA racemase
ANPEP alanyl (membrane) aminopeptidase
ASS1 argininosuccinate synthase 1
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
CBS cystathionine-beta-synthase
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CFI complement factor I
CSTA cystatin A (stefin A)
CXCL6 chemokine (C-X-C motif) ligand 6
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
FADS1 fatty acid desaturase 1
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
GPER1 G protein-coupled estrogen receptor 1
GSTA1 glutathione S-transferase alpha 1
GSTA4 glutathione S-transferase alpha 4
HACD2 3-hydroxyacyl-CoA dehydratase 2
HCP5 HLA complex P5 (non-protein coding)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSDL2 hydroxysteroid dehydrogenase like 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
ISYNA1 inositol-3-phosphate synthase 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LAMA3 laminin, alpha 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
METTL7A methyltransferase like 7A
MMP10 matrix metallopeptidase 10
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
NRIP1 nuclear receptor interacting protein 1
PBLD phenazine biosynthesis-like protein domain containing
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PYCARD PYD and CARD domain containing
S100A8 S100 calcium binding protein A8
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TMEM97 transmembrane protein 97
TSPYL5 TSPY-like 5
TST thiosulfate sulfurtransferase (rhodanese)

decreased expression

Symbol Name
ADAM9 ADAM metallopeptidase domain 9
AKAP12 A kinase (PRKA) anchor protein 12
ANXA1 annexin A1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APP amyloid beta (A4) precursor protein
AREG amphiregulin
ASPH aspartate beta-hydroxylase
C3ORF52 chromosome 3 open reading frame 52
CD9 CD9 molecule
COL1A2 collagen, type I, alpha 2
CRYBG3 beta-gamma crystallin domain containing 3
CST3 cystatin C
CTGF connective tissue growth factor
CTSC cathepsin C
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM198B family with sequence similarity 198, member B
FBN1 fibrillin 1
FGFR1 fibroblast growth factor receptor 1
FOSL1 FOS-like antigen 1
FOXF1 forkhead box F1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GBP1 guanylate binding protein 1, interferon-inducible
HOXB6 homeobox B6
HPCAL1 hippocalcin-like 1
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
ISG15 ISG15 ubiquitin-like modifier
KRT18 keratin 18, type I
KRT8 keratin 8, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MINA MYC induced nuclear antigen
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCB4 phospholipase C, beta 4
PNO1 partner of NOB1 homolog (S. cerevisiae)
PRKCH protein kinase C, eta
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TM9SF3 transmembrane 9 superfamily member 3
TMEM2 transmembrane protein 2
TPM2 tropomyosin 2 (beta)
TSPAN5 tetraspanin 5
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)