BRD-K79259477_KIN001-265_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

320 genes differentially expressed following the BRD-K79259477_KIN001-265_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
ARL8B ADP-ribosylation factor-like 8B
ATP10B ATPase, class V, type 10B
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
BTBD3 BTB (POZ) domain containing 3
C1S complement component 1, s subcomponent
CAPN3 calpain 3, (p94)
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CFB complement factor B
CKB creatine kinase, brain
CLCN3 chloride channel, voltage-sensitive 3
COBL cordon-bleu WH2 repeat protein
COL21A1 collagen, type XXI, alpha 1
CREBL2 cAMP responsive element binding protein-like 2
CTSA cathepsin A
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DUSP1 dual specificity phosphatase 1
ECM1 extracellular matrix protein 1
EFNA1 ephrin-A1
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
FADS1 fatty acid desaturase 1
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GABARAP GABA(A) receptor-associated protein
GALE UDP-galactose-4-epimerase
GAS1 growth arrest-specific 1
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GPX4 glutathione peroxidase 4
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HEXIM1 hexamethylene bis-acetamide inducible 1
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HLA-E major histocompatibility complex, class I, E
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KAZN kazrin, periplakin interacting protein
KIAA1598
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LIMK2 LIM domain kinase 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MARCKSL1 MARCKS-like 1
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MID1 midline 1
MSRB2 methionine sulfoxide reductase B2
MTMR11 myotubularin related protein 11
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NNT nicotinamide nucleotide transhydrogenase
NSG1 neuron specific gene family member 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OPHN1 oligophrenin 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
PBX3 pre-B-cell leukemia homeobox 3
PHYH phytanoyl-CoA 2-hydroxylase
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PNN pinin, desmosome associated protein
PPAP2A phosphatidic acid phosphatase type 2A
PPAP2C phosphatidic acid phosphatase type 2C
PRAF2 PRA1 domain family, member 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYGL phosphorylase, glycogen, liver
RABAC1 Rab acceptor 1 (prenylated)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAGD Ras-related GTP binding D
SCAND1 SCAN domain containing 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEPP1 selenoprotein P, plasma, 1
SERF2 small EDRK-rich factor 2
SFXN3 sideroflexin 3
SLC22A18 solute carrier family 22, member 18
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SREBF1 sterol regulatory element binding transcription factor 1
SSPN sarcospan
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SVIL supervillin
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTA T-cell leukemia translocation altered
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSPAN31 tetraspanin 31
TTC39A tetratricopeptide repeat domain 39A
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WFDC1 WAP four-disulfide core domain 1
XIST X inactive specific transcript (non-protein coding)
ZCCHC24 zinc finger, CCHC domain containing 24

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
COTL1 coactosin-like F-actin binding protein 1
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DBF4 DBF4 zinc finger
DEK DEK proto-oncogene
DEPDC1 DEP domain containing 1
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DSP desmoplakin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EFHD2 EF-hand domain family, member D2
EGR2 early growth response 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGL2 fibrinogen-like 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPR171 G protein-coupled receptor 171
GTPBP4 GTP binding protein 4
GTSE1 G-2 and S-phase expressed 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMK granzyme K (granzyme 3; tryptase II)
HBEGF heparin-binding EGF-like growth factor
HELLS helicase, lymphoid-specific
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IARS isoleucyl-tRNA synthetase
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
ITGB5 integrin, beta 5
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNB1 lamin B1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKI67 marker of proliferation Ki-67
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBPC1 myosin binding protein C, slow type
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAX5 paired box 5
PBK PDZ binding kinase
PDLIM1 PDZ and LIM domain 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLAUR plasminogen activator, urokinase receptor
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PRC1 protein regulator of cytokinesis 1
PRF1 perforin 1 (pore forming protein)
RACGAP1 Rac GTPase activating protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RAN RAN, member RAS oncogene family
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RGS4 regulator of G-protein signaling 4
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SERBP1 SERPINE1 mRNA binding protein 1
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMC4 structural maintenance of chromosomes 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SMYD2 SET and MYND domain containing 2
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
STK17A serine/threonine kinase 17a
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TCL1A T-cell leukemia/lymphoma 1A
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TMEM70 transmembrane protein 70
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRAC T cell receptor alpha constant
TRBC1 T cell receptor beta constant 1
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBA4A tubulin, alpha 4a
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein