BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACLY ATP citrate lyase
ACOT7 acyl-CoA thioesterase 7
ACP5 acid phosphatase 5, tartrate resistant
ADIRF adipogenesis regulatory factor
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF3 activating transcription factor 3
BAG6 BCL2-associated athanogene 6
BEX1 brain expressed, X-linked 1
BRD2 bromodomain containing 2
C7 complement component 7
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CD24 CD24 molecule
CD46 CD46 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHGB chromogranin B
CHL1 cell adhesion molecule L1-like
CKAP4 cytoskeleton-associated protein 4
CLIC1 chloride intracellular channel 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COLEC11 collectin sub-family member 11
CPM carboxypeptidase M
CTGF connective tissue growth factor
CTSL cathepsin L
CTSZ cathepsin Z
CUTA cutA divalent cation tolerance homolog (E. coli)
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAXX death-domain associated protein
DCN decorin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYSL3 dihydropyrimidinase-like 3
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
F12 coagulation factor XII (Hageman factor)
FABP1 fatty acid binding protein 1, liver
FGFR4 fibroblast growth factor receptor 4
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GC group-specific component (vitamin D binding protein)
GPER1 G protein-coupled estrogen receptor 1
GPM6A glycoprotein M6A
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H4C histone cluster 1, H4c
HMGA1 high mobility group AT-hook 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
JUND jun D proto-oncogene
JUP junction plakoglobin
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
L1CAM L1 cell adhesion molecule
LAMP1 lysosomal-associated membrane protein 1
MAB21L2 mab-21-like 2 (C. elegans)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MATN2 matrilin 2
MFAP5 microfibrillar associated protein 5
MXI1 MAX interactor 1, dimerization protein
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PENK proenkephalin
PLAUR plasminogen activator, urokinase receptor
PPT2 palmitoyl-protein thioesterase 2
PRAME preferentially expressed antigen in melanoma
PRR7 proline rich 7 (synaptic)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAI2 retinoic acid induced 2
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RSAD2 radical S-adenosyl methionine domain containing 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPC surfactant protein C
SGPP1 sphingosine-1-phosphate phosphatase 1
SKAP2 src kinase associated phosphoprotein 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SRSF6 serine/arginine-rich splicing factor 6
STK17B serine/threonine kinase 17b
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM14B transmembrane protein 14B
TOX3 TOX high mobility group box family member 3
TSPAN7 tetraspanin 7
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UBE2S ubiquitin-conjugating enzyme E2S
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AUTS2 autism susceptibility candidate 2
BID BH3 interacting domain death agonist
CANT1 calcium activated nucleotidase 1
CBX5 chromobox homolog 5
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDK6 cyclin-dependent kinase 6
CORO1A coronin, actin binding protein, 1A
CRABP2 cellular retinoic acid binding protein 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSK c-src tyrosine kinase
CX3CR1 chemokine (C-X3-C motif) receptor 1
DHRS7B dehydrogenase/reductase (SDR family) member 7B
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FAM129A family with sequence similarity 129, member A
FAM208B family with sequence similarity 208, member B
FAM57A family with sequence similarity 57, member A
GEM GTP binding protein overexpressed in skeletal muscle
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
GTPBP4 GTP binding protein 4
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
IFNGR1 interferon gamma receptor 1
IGFBP5 insulin-like growth factor binding protein 5
IGHMBP2 immunoglobulin mu binding protein 2
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
KAT6A K(lysine) acetyltransferase 6A
KIAA0101 KIAA0101
MACF1 microtubule-actin crosslinking factor 1
MCM10 minichromosome maintenance complex component 10
MTCL1 microtubule crosslinking factor 1
NET1 neuroepithelial cell transforming 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OXTR oxytocin receptor
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PI3 peptidase inhibitor 3, skin-derived
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POU2AF1 POU class 2 associating factor 1
RAD51C RAD51 paralog C
RAE1 ribonucleic acid export 1
RFC2 replication factor C (activator 1) 2, 40kDa
RMI1 RecQ mediated genome instability 1
SIRPA signal-regulatory protein alpha
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD1 SMAD family member 1
SMC1A structural maintenance of chromosomes 1A
TCAF1 TRPM8 channel-associated factor 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TIMELESS timeless circadian clock
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRAPPC3 trafficking protein particle complex 3
UMPS uridine monophosphate synthetase
USP22 ubiquitin specific peptidase 22
VGLL4 vestigial-like family member 4
XIST X inactive specific transcript (non-protein coding)
ZEB1 zinc finger E-box binding homeobox 1
ZMYM2 zinc finger, MYM-type 2
ZNF22 zinc finger protein 22