BRD-K79131256_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K79131256_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APOD apolipoprotein D
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CST1 cystatin SN
CTGF connective tissue growth factor
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
EMP3 epithelial membrane protein 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GLIPR1 GLI pathogenesis-related 1
H3F3B H3 histone, family 3B (H3.3B)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HOMER3 homer scaffolding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
KIF20A kinesin family member 20A
LGALS1 lectin, galactoside-binding, soluble, 1
MEX3D mex-3 RNA binding family member D
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MYBPC2 myosin binding protein C, fast type
MYL1 myosin, light chain 1, alkali; skeletal, fast
NRP1 neuropilin 1
PLIN3 perilipin 3
PLXNB2 plexin B2
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RNF11 ring finger protein 11
SEC62 SEC62 homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMAD3 SMAD family member 3
SMPX small muscle protein, X-linked
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STXBP2 syntaxin binding protein 2
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TNNI2 troponin I type 2 (skeletal, fast)
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L2 tumor protein D52-like 2
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TUBA4A tubulin, alpha 4a
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZYX zyxin

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ASCL1 achaete-scute family bHLH transcription factor 1
ATF6 activating transcription factor 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CCNF cyclin F
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHEK2 checkpoint kinase 2
CPNE3 copine III
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGFL6 EGF-like-domain, multiple 6
ENO2 enolase 2 (gamma, neuronal)
FEN1 flap structure-specific endonuclease 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FMO2 flavin containing monooxygenase 2 (non-functional)
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLS glutaminase
GNPDA1 glucosamine-6-phosphate deaminase 1
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
KDM5D lysine (K)-specific demethylase 5D
KIF2C kinesin family member 2C
MAGED1 melanoma antigen family D1
MBP myelin basic protein
MCM2 minichromosome maintenance complex component 2
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MSH6 mutS homolog 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
NET1 neuroepithelial cell transforming 1
PCNA proliferating cell nuclear antigen
PRKCD protein kinase C, delta
RNASE4 ribonuclease, RNase A family, 4
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEPP1 selenoprotein P, plasma, 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMC2 structural maintenance of chromosomes 2
TACSTD2 tumor-associated calcium signal transducer 2
TENM4 teneurin transmembrane protein 4
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM100 transmembrane protein 100
TMPO thymopoietin
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TUBB tubulin, beta class I
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UBL3 ubiquitin-like 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
VLDLR very low density lipoprotein receptor
XBP1 X-box binding protein 1
ZNF410 zinc finger protein 410
ZWINT ZW10 interacting kinetochore protein