BRD-K79090631_CGP-60474_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

207 genes differentially expressed following the BRD-K79090631_CGP-60474_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
AOX1 aldehyde oxidase 1
ATP13A3 ATPase type 13A3
BID BH3 interacting domain death agonist
CAPG capping protein (actin filament), gelsolin-like
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CELF2 CUGBP, Elav-like family member 2
CEP350 centrosomal protein 350kDa
CEP70 centrosomal protein 70kDa
CES2 carboxylesterase 2
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSB cathepsin B
CTSV cathepsin V
CYBRD1 cytochrome b reductase 1
DEPTOR DEP domain containing MTOR-interacting protein
DLX2 distal-less homeobox 2
DST dystonin
EGR1 early growth response 1
EPHA3 EPH receptor A3
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM134B family with sequence similarity 134, member B
FAM8A1 family with sequence similarity 8, member A1
FHL1 four and a half LIM domains 1
FKBP5 FK506 binding protein 5
FNDC3B fibronectin type III domain containing 3B
FOXC1 forkhead box C1
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLIM4 golgi integral membrane protein 4
GPC3 glypican 3
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
HMGN4 high mobility group nucleosomal binding domain 4
IFITM1 interferon induced transmembrane protein 1
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL2RG interleukin 2 receptor, gamma
IQCK IQ motif containing K
IRS1 insulin receptor substrate 1
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLF9 Kruppel-like factor 9
LAMP3 lysosomal-associated membrane protein 3
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
MAOA monoamine oxidase A
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MATN2 matrilin 2
MCL1 myeloid cell leukemia 1
MGP matrix Gla protein
MT1F metallothionein 1F
MXI1 MAX interactor 1, dimerization protein
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSMR oncostatin M receptor
PAM peptidylglycine alpha-amidating monooxygenase
PAX8 paired box 8
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRD protein tyrosine phosphatase, receptor type, D
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMC1A structural maintenance of chromosomes 1A
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPR signal recognition particle receptor (docking protein)
STC1 stanniocalcin 1
TGFA transforming growth factor, alpha
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TNC tenascin C
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN1 tetraspanin 1
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
WFDC2 WAP four-disulfide core domain 2
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)
ZBTB18 zinc finger and BTB domain containing 18
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTB actin, beta
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
C3ORF14 chromosome 3 open reading frame 14
CASC3 cancer susceptibility candidate 3
CCND1 cyclin D1
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CKS1B CDC28 protein kinase regulatory subunit 1B
CLU clusterin
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4A1 eukaryotic translation initiation factor 4A1
ELOVL1 ELOVL fatty acid elongase 1
ENO1 enolase 1, (alpha)
EXT1 exostosin glycosyltransferase 1
FASN fatty acid synthase
FGFR2 fibroblast growth factor receptor 2
GID8 GID complex subunit 8
H2AFZ H2A histone family, member Z
HN1 hematological and neurological expressed 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ILF2 interleukin enhancer binding factor 2
INHBB inhibin, beta B
JCHAIN joining chain of multimeric IgA and IgM
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDM5D lysine (K)-specific demethylase 5D
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
MAGEA3 melanoma antigen family A3
MARCKS myristoylated alanine-rich protein kinase C substrate
MED24 mediator complex subunit 24
MELK maternal embryonic leucine zipper kinase
MLPH melanophilin
MMP11 matrix metallopeptidase 11
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NET1 neuroepithelial cell transforming 1
NPY1R neuropeptide Y receptor Y1
OPN3 opsin 3
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PFDN4 prefoldin subunit 4
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PON2 paraoxonase 2
PSAP prosaposin
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAE1 ribonucleic acid export 1
RIN2 Ras and Rab interactor 2
RNPS1 RNA binding protein S1, serine-rich domain
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPN2 ribophorin II
RRBP1 ribosome binding protein 1
RRM2 ribonucleotide reductase M2
SCAND1 SCAN domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPE small nuclear ribonucleoprotein polypeptide E
STAU1 staufen double-stranded RNA binding protein 1
TAGLN2 transgelin 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UBE2I ubiquitin-conjugating enzyme E2I
UBE3C ubiquitin protein ligase E3C
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZNF217 zinc finger protein 217