BRD-K79090631_CGP-60474_MDAMB231_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K79090631_CGP-60474_MDAMB231_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COMP cartilage oligomeric matrix protein
CPM carboxypeptidase M
CYFIP2 cytoplasmic FMR1 interacting protein 2
DACH1 dachshund family transcription factor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FABP1 fatty acid binding protein 1, liver
FHL1 four and a half LIM domains 1
IGFBP5 insulin-like growth factor binding protein 5
JAM3 junctional adhesion molecule 3
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LYRM1 LYR motif containing 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MYLK myosin light chain kinase
NPR3 natriuretic peptide receptor 3
PAWR PRKC, apoptosis, WT1, regulator
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG3 paternally expressed 3
PLAT plasminogen activator, tissue
PRAME preferentially expressed antigen in melanoma
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SORD sorbitol dehydrogenase
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TMEM100 transmembrane protein 100
TMSB15A thymosin beta 15a
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4C ADP-ribosylation factor-like 4C
BMP4 bone morphogenetic protein 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CCNF cyclin F
CCR7 chemokine (C-C motif) receptor 7
CDC25A cell division cycle 25A
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNOT4 CCR4-NOT transcription complex, subunit 4
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
FN1 fibronectin 1
FOXC1 forkhead box C1
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLHL21 kelch-like family member 21
KLK5 kallikrein-related peptidase 5
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MID1IP1 MID1 interacting protein 1
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDGFA platelet-derived growth factor alpha polypeptide
PLK2 polo-like kinase 2
PTPRO protein tyrosine phosphatase, receptor type, O
RHOB ras homolog family member B
RNASET2 ribonuclease T2
RPP38 ribonuclease P/MRP 38kDa subunit
S100A8 S100 calcium binding protein A8
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SLC43A3 solute carrier family 43, member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRSF6 serine/arginine-rich splicing factor 6
TACSTD2 tumor-associated calcium signal transducer 2
TOB1 transducer of ERBB2, 1
TUBA4A tubulin, alpha 4a
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2