BRD-K79090631_CGP-60474_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

211 genes differentially expressed following the BRD-K79090631_CGP-60474_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR3 atypical chemokine receptor 3
ACOT7 acyl-CoA thioesterase 7
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHCY adenosylhomocysteinase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
BHMT2 betaine--homocysteine S-methyltransferase 2
C1R complement component 1, r subcomponent
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CD1B CD1b molecule
CD48 CD48 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CES1 carboxylesterase 1
CETN2 centrin, EF-hand protein, 2
CH25H cholesterol 25-hydroxylase
CKB creatine kinase, brain
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CXORF57 chromosome X open reading frame 57
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPT dermatopontin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR2 early growth response 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
ESD esterase D
ESR1 estrogen receptor 1
FAM107A family with sequence similarity 107, member A
FAM46A family with sequence similarity 46, member A
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FRZB frizzled-related protein
FXYD1 FXYD domain containing ion transport regulator 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUK1 guanylate kinase 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTRA1 HtrA serine peptidase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KDM4B lysine (K)-specific demethylase 4B
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LGMN legumain
LRRC17 leucine rich repeat containing 17
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1C1 mannosidase, alpha, class 1C, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MFAP4 microfibrillar-associated protein 4
MMP1 matrix metallopeptidase 1
MSX1 msh homeobox 1
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOTCH3 notch 3
OSBPL1A oxysterol binding protein-like 1A
PCBP2 poly(rC) binding protein 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROS1 protein S (alpha)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAI2 retinoic acid induced 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAD Ras-related associated with diabetes
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMYD3 SET and MYND domain containing 3
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SSR4 signal sequence receptor, delta
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
THY1 Thy-1 cell surface antigen
TICAM1 toll-like receptor adaptor molecule 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ASXL2 additional sex combs like transcriptional regulator 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLMH bleomycin hydrolase
BMI1 BMI1 proto-oncogene, polycomb ring finger
BUB3 BUB3 mitotic checkpoint protein
CALML5 calmodulin-like 5
CANT1 calcium activated nucleotidase 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEP55 centrosomal protein 55kDa
CTBP2 C-terminal binding protein 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
FEN1 flap structure-specific endonuclease 1
H1F0 H1 histone family, member 0
H2AFX H2A histone family, member X
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LMNB1 lamin B1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYO10 myosin X
NF1 neurofibromin 1
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTPRE protein tyrosine phosphatase, receptor type, E
RAB14 RAB14, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBBP4 retinoblastoma binding protein 4
RNPS1 RNA binding protein S1, serine-rich domain
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SYNRG synergin, gamma
TMED2 transmembrane emp24 domain trafficking protein 2
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TMX4 thioredoxin-related transmembrane protein 4
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNS3 tensin 3
TXLNA taxilin alpha
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
VCAN versican
WSB1 WD repeat and SOCS box containing 1
XPO1 exportin 1
XPO7 exportin 7
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZDHHC6 zinc finger, DHHC-type containing 6