BRD-K79090631_CGP-60474_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

263 genes differentially expressed following the BRD-K79090631_CGP-60474_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AEBP1 AE binding protein 1
AHCY adenosylhomocysteinase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AREG amphiregulin
ASPN asporin
ATF3 activating transcription factor 3
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BCAP31 B-cell receptor-associated protein 31
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
C6ORF62 chromosome 6 open reading frame 62
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
COBL cordon-bleu WH2 repeat protein
COL10A1 collagen, type X, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COMP cartilage oligomeric matrix protein
COTL1 coactosin-like F-actin binding protein 1
CTGF connective tissue growth factor
CTTN cortactin
CYR61 cysteine-rich, angiogenic inducer, 61
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FABP7 fatty acid binding protein 7, brain
FAM134B family with sequence similarity 134, member B
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2BD histone cluster 1, H2bd
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IFI6 interferon, alpha-inducible protein 6
IGFBP3 insulin-like growth factor binding protein 3
ITM2A integral membrane protein 2A
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LAGE3 L antigen family, member 3
LAPTM5 lysosomal protein transmembrane 5
LGALS1 lectin, galactoside-binding, soluble, 1
LIMA1 LIM domain and actin binding 1
LRRC15 leucine rich repeat containing 15
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MPPED2 metallophosphoesterase domain containing 2
MTUS1 microtubule associated tumor suppressor 1
MYL12B myosin, light chain 12B, regulatory
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPR3 natriuretic peptide receptor 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NSF N-ethylmaleimide-sensitive factor
NTS neurotensin
PECAM1 platelet/endothelial cell adhesion molecule 1
PGK1 phosphoglycerate kinase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLBD1 phospholipase B domain containing 1
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PRNP prion protein
RBKS ribokinase
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RPL26L1 ribosomal protein L26-like 1
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPP1 secreted phosphoprotein 1
STMN2 stathmin 2
TAGLN transgelin
TAL1 T-cell acute lymphocytic leukemia 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TPGS2 tubulin polyglutamylase complex subunit 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
VAT1 vesicle amine transport 1
VWF von Willebrand factor

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG5 BCL2-associated athanogene 5
BARD1 BRCA1 associated RING domain 1
BTG1 B-cell translocation gene 1, anti-proliferative
C9ORF3 chromosome 9 open reading frame 3
CA12 carbonic anhydrase XII
CCNE2 cyclin E2
CCNF cyclin F
CCNJ cyclin J
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK17 cyclin-dependent kinase 17
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CSTA cystatin A (stefin A)
CXCL11 chemokine (C-X-C motif) ligand 11
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
EMX2 empty spiracles homeobox 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FBXO34 F-box protein 34
FBXO5 F-box protein 5
FEM1B fem-1 homolog b (C. elegans)
FKBP5 FK506 binding protein 5
FN1 fibronectin 1
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GRB7 growth factor receptor-bound protein 7
HES1 hes family bHLH transcription factor 1
HNMT histamine N-methyltransferase
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IER5 immediate early response 5
INTS6 integrator complex subunit 6
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KCTD12 potassium channel tetramerization domain containing 12
KIN Kin17 DNA and RNA binding protein
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LCN2 lipocalin 2
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MNDA myeloid cell nuclear differentiation antigen
MTF2 metal response element binding transcription factor 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDZRN3 PDZ domain containing ring finger 3
PEG10 paternally expressed 10
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAV1 salvador family WW domain containing protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD3 SERTA domain containing 3
SETBP1 SET binding protein 1
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SIRT1 sirtuin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRY2 sprouty homolog 2 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
STAR steroidogenic acute regulatory protein
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TP53BP2 tumor protein p53 binding protein 2
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
USP1 ubiquitin specific peptidase 1
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
ZBED5 zinc finger, BED-type containing 5
ZBTB16 zinc finger and BTB domain containing 16
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZNF217 zinc finger protein 217
ZNF318 zinc finger protein 318