BRD-K79090631_CGP-60474_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

375 genes differentially expressed following the BRD-K79090631_CGP-60474_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR3 atypical chemokine receptor 3
ACSS3 acyl-CoA synthetase short-chain family member 3
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AKAP12 A kinase (PRKA) anchor protein 12
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
ANXA9 annexin A9
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATG12 autophagy related 12
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATXN1 ataxin 1
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
C1ORF54 chromosome 1 open reading frame 54
C2CD2L C2CD2-like
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD34 CD34 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD4 CD4 molecule
CD52 CD52 molecule
CD84 CD84 molecule
CD9 CD9 molecule
CD99 CD99 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CECR1 cat eye syndrome chromosome region, candidate 1
CEP70 centrosomal protein 70kDa
CFB complement factor B
CFD complement factor D (adipsin)
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
CLU clusterin
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTTN cortactin
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DACH1 dachshund family transcription factor 1
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
ECM1 extracellular matrix protein 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FRY furry homolog (Drosophila)
G0S2 G0/G1 switch 2
GAGE3 G antigen 3
GATA3 GATA binding protein 3
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
GUSBP3 glucuronidase, beta pseudogene 3
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBB hemoglobin, beta
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HILPDA hypoxia inducible lipid droplet-associated
HIP1 huntingtin interacting protein 1
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R1 interleukin 1 receptor, type I
IL2RG interleukin 2 receptor, gamma
IL6 interleukin 6
IL7R interleukin 7 receptor
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAM2 junctional adhesion molecule 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD12 potassium channel tetramerization domain containing 12
LDOC1 leucine zipper, down-regulated in cancer 1
LEF1 lymphoid enhancer-binding factor 1
LOX lysyl oxidase
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC16A leucine rich repeat containing 16A
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAN1C1 mannosidase, alpha, class 1C, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MECOM MDS1 and EVI1 complex locus
MED13L mediator complex subunit 13-like
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
MFAP2 microfibrillar-associated protein 2
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYLK myosin light chain kinase
NDRG1 N-myc downstream regulated 1
NOX4 NADPH oxidase 4
NTM neurotrimin
OPTN optineurin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLIN1 perilipin 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS21 protease, serine, 21 (testisin)
PRSS23 protease, serine, 23
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RAB17 RAB17, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
REEP5 receptor accessory protein 5
RELN reelin
RGS5 regulator of G-protein signaling 5
RNASE4 ribonuclease, RNase A family, 4
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCD5 stearoyl-CoA desaturase 5
SDC2 syndecan 2
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC38A1 solute carrier family 38, member 1
SMA4 glucuronidase, beta pseudogene
SPARCL1 SPARC-like 1 (hevin)
SSR4 signal sequence receptor, delta
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF4 transcription factor 4
TEK TEK tyrosine kinase, endothelial
TF transferrin
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS4 thrombospondin 4
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TPP1 tripeptidyl peptidase I
TRAC T cell receptor alpha constant
TRAK2 trafficking protein, kinesin binding 2
TRBC1 T cell receptor beta constant 1
TRD T cell receptor delta locus
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
VAMP7 vesicle-associated membrane protein 7
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZNF148 zinc finger protein 148
ZNF264 zinc finger protein 264
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADRB2 adrenoceptor beta 2, surface
ADSL adenylosuccinate lyase
AGTR1 angiotensin II receptor, type 1
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C1ORF116 chromosome 1 open reading frame 116
CACYBP calcyclin binding protein
CARD10 caspase recruitment domain family, member 10
CCNA2 cyclin A2
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CKS2 CDC28 protein kinase regulatory subunit 2
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
COPS7A COP9 signalosome subunit 7A
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
DSC3 desmocollin 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF3B eukaryotic translation initiation factor 3, subunit B
EIF4E eukaryotic translation initiation factor 4E
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBL fibrillarin
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
H2AFZ H2A histone family, member Z
HEATR1 HEAT repeat containing 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOXA5 homeobox A5
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ILF2 interleukin enhancer binding factor 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KARS lysyl-tRNA synthetase
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KLK5 kallikrein-related peptidase 5
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LBR lamin B receptor
LDLR low density lipoprotein receptor
LRRC59 leucine rich repeat containing 59
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MICALL1 MICAL-like 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP2 matrix metallopeptidase 2
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PHB prohibitin
PKP1 plakophilin 1
PLAC8 placenta-specific 8
PNP purine nucleoside phosphorylase
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTBP1 polypyrimidine tract binding protein 1
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RNPS1 RNA binding protein S1, serine-rich domain
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCAND1 SCAN domain containing 1
SERBP1 SERPINE1 mRNA binding protein 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLIRP SRA stem-loop interacting RNA binding protein
SNAI2 snail family zinc finger 2
SNAP25 synaptosomal-associated protein, 25kDa
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPINK1 serine peptidase inhibitor, Kazal type 1
STOML2 stomatin (EPB72)-like 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCP1 t-complex 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRAPPC3 trafficking protein particle complex 3
TRIM29 tripartite motif containing 29
TRIP6 thyroid hormone receptor interactor 6
TUBA4A tubulin, alpha 4a
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
U2AF1 U2 small nuclear RNA auxiliary factor 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2I ubiquitin-conjugating enzyme E2I
UBE2S ubiquitin-conjugating enzyme E2S
USP22 ubiquitin specific peptidase 22
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VCP valosin containing protein
WEE1 WEE1 G2 checkpoint kinase
YBX3 Y box binding protein 3