BRD-K79090631_CGP-60474_MCF10A_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

307 genes differentially expressed following the BRD-K79090631_CGP-60474_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACKR3 atypical chemokine receptor 3
ACSM5 acyl-CoA synthetase medium-chain family member 5
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
ANXA9 annexin A9
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP9 aquaporin 9
ATG12 autophagy related 12
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BLNK B-cell linker
CADM1 cell adhesion molecule 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD99 CD99 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFB complement factor B
CFI complement factor I
CHMP6 charged multivesicular body protein 6
CNN1 calponin 1, basic, smooth muscle
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DOK5 docking protein 5
EFNB2 ephrin-B2
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
EXOSC4 exosome component 4
F8 coagulation factor VIII, procoagulant component
FAM107A family with sequence similarity 107, member A
FAM134B family with sequence similarity 134, member B
FAM216A family with sequence similarity 216, member A
FBLN1 fibulin 1
FBN1 fibrillin 1
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FKBP11 FK506 binding protein 11, 19 kDa
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAP43 growth associated protein 43
GAS1 growth arrest-specific 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPC3 glypican 3
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXD3 homeobox D3
HRH1 histamine receptor H1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IQCK IQ motif containing K
JAM2 junctional adhesion molecule 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KRT19 keratin 19, type I
LEPROT leptin receptor overlapping transcript
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRN3 leucine rich repeat neuronal 3
LY86 lymphocyte antigen 86
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP2 microtubule-associated protein 2
MATN2 matrilin 2
MBP myelin basic protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MMP7 matrix metallopeptidase 7
MXRA5 matrix-remodelling associated 5
NDP Norrie disease (pseudoglioma)
NEB nebulin
NQO1 NAD(P)H dehydrogenase, quinone 1
OBSL1 obscurin-like 1
OPTN optineurin
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PER2 period circadian clock 2
PFKL phosphofructokinase, liver
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLIN1 perilipin 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAP2C RAP2C, member of RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
REEP5 receptor accessory protein 5
REG1A regenerating islet-derived 1 alpha
RHOBTB3 Rho-related BTB domain containing 3
RNASET2 ribonuclease T2
S100A7 S100 calcium binding protein A7
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SEPT6 septin 6
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SH3BGR SH3 domain binding glutamate-rich protein
SLC38A1 solute carrier family 38, member 1
SLPI secretory leukocyte peptidase inhibitor
SPARCL1 SPARC-like 1 (hevin)
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
STK26 serine/threonine protein kinase 26
STMN2 stathmin 2
SULF1 sulfatase 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TM4SF4 transmembrane 4 L six family member 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPSAB1 tryptase alpha/beta 1
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TWIST1 twist family bHLH transcription factor 1
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VEGFC vascular endothelial growth factor C
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1
ZNF423 zinc finger protein 423
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADI1 acireductone dioxygenase 1
AKAP1 A kinase (PRKA) anchor protein 1
ALCAM activated leukocyte cell adhesion molecule
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
ATF5 activating transcription factor 5
ATG3 autophagy related 3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BEX1 brain expressed, X-linked 1
C1ORF116 chromosome 1 open reading frame 116
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV2 caveolin 2
CCNA2 cyclin A2
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CHMP4A charged multivesicular body protein 4A
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC2B C-type lectin domain family 2, member B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CST7 cystatin F (leukocystatin)
DDIT4 DNA-damage-inducible transcript 4
DESI2 desumoylating isopeptidase 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
EIF4E eukaryotic translation initiation factor 4E
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV1 ets variant 1
EXT1 exostosin glycosyltransferase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOXF1 forkhead box F1
FZD7 frizzled class receptor 7
GCH1 GTP cyclohydrolase 1
GLOD4 glyoxalase domain containing 4
GLRX glutaredoxin (thioltransferase)
HBEGF heparin-binding EGF-like growth factor
HOXC10 homeobox C10
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGAV integrin, alpha V
JADE2 jade family PHD finger 2
KIAA0226L KIAA0226-like
KIF14 kinesin family member 14
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT5 keratin 5, type II
LAP3 leucine aminopeptidase 3
LBR lamin B receptor
LDLR low density lipoprotein receptor
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MAPK13 mitogen-activated protein kinase 13
MELK maternal embryonic leucine zipper kinase
MICALL1 MICAL-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMB microseminoprotein, beta-
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
NDC80 NDC80 kinetochore complex component
NEBL nebulette
NKX3-1 NK3 homeobox 1
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRP1 neuropilin 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCNA proliferating cell nuclear antigen
PKP1 plakophilin 1
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PNP purine nucleoside phosphorylase
PPAP2C phosphatidic acid phosphatase type 2C
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTPRD protein tyrosine phosphatase, receptor type, D
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS1 regulator of G-protein signaling 1
RND3 Rho family GTPase 3
RRM2 ribonucleotide reductase M2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMC4 structural maintenance of chromosomes 4
SORBS2 sorbin and SH3 domain containing 2
SPATS2L spermatogenesis associated, serine-rich 2-like
TARP TCR gamma alternate reading frame protein
TBL1X transducin (beta)-like 1X-linked
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM100 transmembrane protein 100
TOP2A topoisomerase (DNA) II alpha 170kDa
TPMT thiopurine S-methyltransferase
TRBC1 T cell receptor beta constant 1
TTLL12 tubulin tyrosine ligase-like family member 12
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
TYMS thymidylate synthetase
UBE3C ubiquitin protein ligase E3C
UCK2 uridine-cytidine kinase 2
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VEGFA vascular endothelial growth factor A