BRD-K79090631_CGP-60474_LNCAP_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K79090631_CGP-60474_LNCAP_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ANXA5 annexin A5
AQP9 aquaporin 9
BST2 bone marrow stromal cell antigen 2
CFB complement factor B
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COCH cochlin
CPVL carboxypeptidase, vitellogenic-like
CTTN cortactin
DPYD dihydropyrimidine dehydrogenase
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
G0S2 G0/G1 switch 2
HOXC10 homeobox C10
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KYNU kynureninase
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTA4H leukotriene A4 hydrolase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NID2 nidogen 2 (osteonidogen)
NKTR natural killer cell triggering receptor
NMU neuromedin U
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NTS neurotensin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PPAP2C phosphatidic acid phosphatase type 2C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PXDN peroxidasin
RAB31 RAB31, member RAS oncogene family
RHOQ ras homolog family member Q
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TSPAN31 tetraspanin 31
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1ORF106 chromosome 1 open reading frame 106
C8ORF4 chromosome 8 open reading frame 4
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5 eukaryotic translation initiation factor 5
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FCGBP Fc fragment of IgG binding protein
FZD5 frizzled class receptor 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA2 GATA binding protein 2
GLDC glycine dehydrogenase (decarboxylating)
GPNMB glycoprotein (transmembrane) nmb
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIC2 hypermethylated in cancer 2
HILPDA hypoxia inducible lipid droplet-associated
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KAZN kazrin, periplakin interacting protein
KLF4 Kruppel-like factor 4 (gut)
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MSX1 msh homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NRCAM neuronal cell adhesion molecule
NXT1 nuclear transport factor 2-like export factor 1
PER2 period circadian clock 2
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPAP2B phosphatidic acid phosphatase type 2B
PRDM2 PR domain containing 2, with ZNF domain
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RBM15 RNA binding motif protein 15
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SERTAD3 SERTA domain containing 3
SIK1 salt-inducible kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNAI2 snail family zinc finger 2
TBX3 T-box 3
TFF3 trefoil factor 3 (intestinal)
TICAM1 toll-like receptor adaptor molecule 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM70 transmembrane protein 70
TOB1 transducer of ERBB2, 1
TUBA4A tubulin, alpha 4a
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2