BRD-K79090631_CGP-60474_LNCAP_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

265 genes differentially expressed following the BRD-K79090631_CGP-60474_LNCAP_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ACP1 acid phosphatase 1, soluble
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANKRD36B ankyrin repeat domain 36B
AOX1 aldehyde oxidase 1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AQP1 aquaporin 1 (Colton blood group)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
C5AR1 complement component 5a receptor 1
CADM1 cell adhesion molecule 1
CAT catalase
CAV2 caveolin 2
CD46 CD46 molecule, complement regulatory protein
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CETN2 centrin, EF-hand protein, 2
CFLAR CASP8 and FADD-like apoptosis regulator
COG5 component of oligomeric golgi complex 5
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CTGF connective tissue growth factor
CTTN cortactin
CYB561 cytochrome b561
CYBRD1 cytochrome b reductase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DENND2D DENN/MADD domain containing 2D
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL3 dihydropyrimidinase-like 3
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GPC4 glypican 4
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-G major histocompatibility complex, class I, G
HMGN5 high mobility group nucleosome binding domain 5
HRSP12 heat-responsive protein 12
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTA4H leukotriene A4 hydrolase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN1A1 mannosidase, alpha, class 1A, member 1
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MPP1 membrane protein, palmitoylated 1, 55kDa
MSRB1 methionine sulfoxide reductase B1
MT1F metallothionein 1F
MT1M metallothionein 1M
MXRA7 matrix-remodelling associated 7
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB1 nucleobindin 1
OSBPL10 oxysterol binding protein-like 10
PAM peptidylglycine alpha-amidating monooxygenase
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZD2 PDZ domain containing 2
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PYGL phosphorylase, glycogen, liver
QPRT quinolinate phosphoribosyltransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNF130 ring finger protein 130
RSAD2 radical S-adenosyl methionine domain containing 2
S100A11 S100 calcium binding protein A11
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT6 septin 6
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SSR4 signal sequence receptor, delta
STC1 stanniocalcin 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TGFB1 transforming growth factor, beta 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TSTA3 tissue specific transplantation antigen P35B
TTC3 tetratricopeptide repeat domain 3
TUBB2B tubulin, beta 2B class IIb
TYROBP TYRO protein tyrosine kinase binding protein
VAMP7 vesicle-associated membrane protein 7
VAMP8 vesicle-associated membrane protein 8
WFDC2 WAP four-disulfide core domain 2
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
AKAP1 A kinase (PRKA) anchor protein 1
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ARF6 ADP-ribosylation factor 6
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASS1 argininosuccinate synthase 1
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
BAG3 BCL2-associated athanogene 3
C1ORF116 chromosome 1 open reading frame 116
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHERP calcium homeostasis endoplasmic reticulum protein
CHMP7 charged multivesicular body protein 7
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT7 CCR4-NOT transcription complex, subunit 7
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSNK1D casein kinase 1, delta
CXCL14 chemokine (C-X-C motif) ligand 14
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
DUSP7 dual specificity phosphatase 7
ERBB2 erb-b2 receptor tyrosine kinase 2
FCGBP Fc fragment of IgG binding protein
FOXO3 forkhead box O3
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GAS1 growth arrest-specific 1
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GEMIN4 gem (nuclear organelle) associated protein 4
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPATCH8 G patch domain containing 8
GPX2 glutathione peroxidase 2
GRB10 growth factor receptor-bound protein 10
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
LIMCH1 LIM and calponin homology domains 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAK16 MAK16 homolog (S. cerevisiae)
MAPK6 mitogen-activated protein kinase 6
MAT2A methionine adenosyltransferase II, alpha
MB myoglobin
MED1 mediator complex subunit 1
MED17 mediator complex subunit 17
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFYA nuclear transcription factor Y, alpha
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOL11 nucleolar protein 11
NOP56 NOP56 ribonucleoprotein
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PCGF2 polycomb group ring finger 2
PCNA proliferating cell nuclear antigen
PDCD2 programmed cell death 2
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PNP purine nucleoside phosphorylase
PRKCD protein kinase C, delta
PRPF4B pre-mRNA processing factor 4B
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PUM1 pumilio RNA-binding family member 1
RAB14 RAB14, member RAS oncogene family
RAE1 ribonucleic acid export 1
RNPS1 RNA binding protein S1, serine-rich domain
SACS sacsin molecular chaperone
SCAND1 SCAN domain containing 1
SEC24B SEC24 family member B
SIK1 salt-inducible kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBP TATA box binding protein
TFAM transcription factor A, mitochondrial
TFB2M transcription factor B2, mitochondrial
TMEM70 transmembrane protein 70
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOX3 TOX high mobility group box family member 3
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM29 tripartite motif containing 29
TXLNA taxilin alpha
UBAP2L ubiquitin associated protein 2-like
USP22 ubiquitin specific peptidase 22
USP3 ubiquitin specific peptidase 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WDR82 WD repeat domain 82
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2