BRD-K79090631_CGP-60474_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

432 genes differentially expressed following the BRD-K79090631_CGP-60474_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOLD1 apolipoprotein L domain containing 1
ARMCX2 armadillo repeat containing, X-linked 2
ATF3 activating transcription factor 3
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BACE2 beta-site APP-cleaving enzyme 2
BCHE butyrylcholinesterase
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CELF2 CUGBP, Elav-like family member 2
CERS6 ceramide synthase 6
CFI complement factor I
CH25H cholesterol 25-hydroxylase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP1B charged multivesicular body protein 1B
CLDN10 claudin 10
CLEC11A C-type lectin domain family 11, member A
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL21A1 collagen, type XXI, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COLEC12 collectin sub-family member 12
CRIP2 cysteine-rich protein 2
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTSB cathepsin B
CTSL cathepsin L
CTSO cathepsin O
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DST dystonin
DUSP10 dual specificity phosphatase 10
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNLT3 dynein, light chain, Tctex-type 3
ECHDC2 enoyl CoA hydratase domain containing 2
ECM1 extracellular matrix protein 1
EDNRA endothelin receptor type A
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM107A family with sequence similarity 107, member A
FAM129A family with sequence similarity 129, member A
FAM49A family with sequence similarity 49, member A
FAM63A family with sequence similarity 63, member A
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FRY furry homolog (Drosophila)
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GATAD1 GATA zinc finger domain containing 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GHR growth hormone receptor
GOLGA8A golgin A8 family, member A
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPRASP1 G protein-coupled receptor associated sorting protein 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
HBE1 hemoglobin, epsilon 1
HBEGF heparin-binding EGF-like growth factor
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INHBA inhibin, beta A
INPP5F inositol polyphosphate-5-phosphatase F
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LOC100272216 uncharacterized LOC100272216
LOX lysyl oxidase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEB2 melanoma antigen family B2
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MEF2C myocyte enhancer factor 2C
MEG3 maternally expressed 3 (non-protein coding)
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MICB MHC class I polypeptide-related sequence B
MPPE1 metallophosphoesterase 1
MSLN mesothelin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
NCAM1 neural cell adhesion molecule 1
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NFIL3 nuclear factor, interleukin 3 regulated
NID2 nidogen 2 (osteonidogen)
NMU neuromedin U
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
NQO2 NAD(P)H dehydrogenase, quinone 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTS neurotensin
NUCB1 nucleobindin 1
OLFM1 olfactomedin 1
OSBPL1A oxysterol binding protein-like 1A
PALLD palladin, cytoskeletal associated protein
PAM peptidylglycine alpha-amidating monooxygenase
PCBP2 poly(rC) binding protein 2
PCCA propionyl CoA carboxylase, alpha polypeptide
PCDH17 protocadherin 17
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE4DIP phosphodiesterase 4D interacting protein
PDE8B phosphodiesterase 8B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROS1 protein S (alpha)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RHOBTB3 Rho-related BTB domain containing 3
RNMT RNA (guanine-7-) methyltransferase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SECISBP2L SECIS binding protein 2-like
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SF1 splicing factor 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMYD3 SET and MYND domain containing 3
SNX10 sorting nexin 10
SOCS3 suppressor of cytokine signaling 3
SORD sorbitol dehydrogenase
SPEN spen family transcriptional repressor
SPON1 spondin 1, extracellular matrix protein
SQRDL sulfide quinone reductase-like (yeast)
SRSF11 serine/arginine-rich splicing factor 11
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SYT1 synaptotagmin I
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNT1 troponin T type 1 (skeletal, slow)
TP53TG1 TP53 target 1 (non-protein coding)
TPO thyroid peroxidase
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TRIB2 tribbles pseudokinase 2
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI
WBP5 WW domain binding protein 5
WFDC2 WAP four-disulfide core domain 2
XAF1 XIAP associated factor 1
XYLT1 xylosyltransferase I
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB20 zinc finger and BTB domain containing 20
ZDHHC11 zinc finger, DHHC-type containing 11
ZEB1 zinc finger E-box binding homeobox 1
ZMAT3 zinc finger, matrin-type 3
ZNF264 zinc finger protein 264
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAM10 ADAM metallopeptidase domain 10
AIM1 absent in melanoma 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA3 annexin A3
ANXA7 annexin A7
ATG3 autophagy related 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
CA1 carbonic anhydrase I
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNC cyclin C
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD164 CD164 molecule, sialomucin
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP57 centrosomal protein 57kDa
CHGB chromogranin B
CLTC clathrin, heavy chain (Hc)
CPA3 carboxypeptidase A3 (mast cell)
CTBP2 C-terminal binding protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
DCK deoxycytidine kinase
DCN decorin
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EGLN2 egl-9 family hypoxia-inducible factor 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELF5 E74-like factor 5 (ets domain transcription factor)
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM208B family with sequence similarity 208, member B
FAM69A family with sequence similarity 69, member A
FBL fibrillarin
FCGBP Fc fragment of IgG binding protein
FERMT1 fermitin family member 1
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
H1F0 H1 histone family, member 0
HBD hemoglobin, delta
HEATR1 HEAT repeat containing 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HN1L hematological and neurological expressed 1-like
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ITGB1BP1 integrin beta 1 binding protein 1
IVNS1ABP influenza virus NS1A binding protein
JMJD6 jumonji domain containing 6
KCTD12 potassium channel tetramerization domain containing 12
KLF5 Kruppel-like factor 5 (intestinal)
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
LAMB1 laminin, beta 1
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL1 muscleblind-like splicing regulator 1
MBNL2 muscleblind-like splicing regulator 2
MCM3 minichromosome maintenance complex component 3
MELK maternal embryonic leucine zipper kinase
MID1IP1 MID1 interacting protein 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP7 matrix metallopeptidase 7
MRPS30 mitochondrial ribosomal protein S30
MYO5C myosin VC
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOP56 NOP56 ribonucleoprotein
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUP62 nucleoporin 62kDa
OXA1L oxidase (cytochrome c) assembly 1-like
PADI2 peptidyl arginine deiminase, type II
PCNA proliferating cell nuclear antigen
PDZRN3 PDZ domain containing ring finger 3
PLEC plectin
PLK1 polo-like kinase 1
PLXND1 plexin D1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RNPS1 RNA binding protein S1, serine-rich domain
RPL37A ribosomal protein L37a
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC35F2 solute carrier family 35, member F2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF1 serine/arginine-rich splicing factor 1
STAB1 stabilin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAGLN2 transgelin 2
TARP TCR gamma alternate reading frame protein
TCTN1 tectonic family member 1
TEX10 testis expressed 10
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TM9SF3 transmembrane 9 superfamily member 3
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNIP1 TNFAIP3 interacting protein 1
TNS1 tensin 1
TNS3 tensin 3
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TRIM14 tripartite motif containing 14
TRIM29 tripartite motif containing 29
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UBE2I ubiquitin-conjugating enzyme E2I
UBE3C ubiquitin protein ligase E3C
XBP1 X-box binding protein 1
XPO7 exportin 7
YBX3 Y box binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon