BRD-K79090631_CGP-60474_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

311 genes differentially expressed following the BRD-K79090631_CGP-60474_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
APOD apolipoprotein D
ARL3 ADP-ribosylation factor-like 3
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BLNK B-cell linker
C3 complement component 3
CCND2 cyclin D2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIC5 chloride intracellular channel 5
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
COMP cartilage oligomeric matrix protein
CSTA cystatin A (stefin A)
CYBB cytochrome b-245, beta polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCN decorin
DES desmin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
FADS2 fatty acid desaturase 2
FBLN1 fibulin 1
FGFR1 fibroblast growth factor receptor 1
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPC4 glypican 4
GPER1 G protein-coupled estrogen receptor 1
GPM6A glycoprotein M6A
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GUSBP3 glucuronidase, beta pseudogene 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0226L KIAA0226-like
KIAA0485 uncharacterized LOC57235
LOC100272216 uncharacterized LOC100272216
LTA4H leukotriene A4 hydrolase
LTBP1 latent transforming growth factor beta binding protein 1
LTBP3 latent transforming growth factor beta binding protein 3
MAOA monoamine oxidase A
MTUS1 microtubule associated tumor suppressor 1
MXRA5 matrix-remodelling associated 5
NMU neuromedin U
NREP neuronal regeneration related protein
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEX11A peroxisomal biogenesis factor 11 alpha
POSTN periostin, osteoblast specific factor
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGS10 regulator of G-protein signaling 10
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL31 ribosomal protein L31
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPW1 selenoprotein W, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMA4 glucuronidase, beta pseudogene
SPON1 spondin 1, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPGS2 tubulin polyglutamylase complex subunit 2
VAV3 vav 3 guanine nucleotide exchange factor
VWA5A von Willebrand factor A domain containing 5A
XIST X inactive specific transcript (non-protein coding)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
AHR aryl hydrocarbon receptor
AMD1 adenosylmethionine decarboxylase 1
AMOTL2 angiomotin like 2
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4A ADP-ribosylation factor-like 4A
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL10 B-cell CLL/lymphoma 10
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1ORF106 chromosome 1 open reading frame 106
CALML3 calmodulin-like 3
CALML5 calmodulin-like 5
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CCNL1 cyclin L1
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COIL coilin
CRISP3 cysteine-rich secretory protein 3
CSNK1E casein kinase 1, epsilon
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F3 E2F transcription factor 3
EDN1 endothelin 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FBXO5 F-box protein 5
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXG1 forkhead box G1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2B general transcription factor IIB
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HOXA1 homeobox A1
HOXA10 homeobox A10
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGKV4-1 immunoglobulin kappa variable 4-1
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KDM3A lysine (K)-specific demethylase 3A
KIF20A kinesin family member 20A
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MCOLN1 mucolipin 1
MED17 mediator complex subunit 17
MIR22HG MIR22 host gene
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
OSER1 oxidative stress responsive serine-rich 1
PELO pelota homolog (Drosophila)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTX3 pentraxin 3, long
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RBM7 RNA binding motif protein 7
RBMS1 RNA binding motif, single stranded interacting protein 1
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SAP30 Sin3A-associated protein, 30kDa
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB1 transducer of ERBB2, 1
TSC22D2 TSC22 domain family, member 2
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
ZNF267 zinc finger protein 267