BRD-K79090631_CGP-60474_HS578T_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-K79090631_CGP-60474_HS578T_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANPEP alanyl (membrane) aminopeptidase
ANXA5 annexin A5
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ARL3 ADP-ribosylation factor-like 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
C3 complement component 3
CAV2 caveolin 2
CCPG1 cell cycle progression 1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CHGB chromogranin B
COG5 component of oligomeric golgi complex 5
COL3A1 collagen, type III, alpha 1
COMP cartilage oligomeric matrix protein
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CST3 cystatin C
CXCL14 chemokine (C-X-C motif) ligand 14
CYBB cytochrome b-245, beta polypeptide
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DMBT1 deleted in malignant brain tumors 1
DMD dystrophin
EIF5A eukaryotic translation initiation factor 5A
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GALC galactosylceramidase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLG1 golgi glycoprotein 1
GSN gelsolin
H2AFY H2A histone family, member Y
HIST1H1C histone cluster 1, H1c
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFI6 interferon, alpha-inducible protein 6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL6ST interleukin 6 signal transducer
ITGAV integrin, alpha V
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LAMB3 laminin, beta 3
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPL lipoprotein lipase
LTBP1 latent transforming growth factor beta binding protein 1
LYRM1 LYR motif containing 1
LYZ lysozyme
MAOA monoamine oxidase A
MXRA5 matrix-remodelling associated 5
MYO1B myosin IB
NBPF10 neuroblastoma breakpoint family, member 10
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NMU neuromedin U
NPTN neuroplastin
NT5E 5'-nucleotidase, ecto (CD73)
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PNMA2 paraneoplastic Ma antigen 2
PPT1 palmitoyl-protein thioesterase 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RBKS ribokinase
RPL31 ribosomal protein L31
RTN1 reticulon 1
RTN3 reticulon 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SPARCL1 SPARC-like 1 (hevin)
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TSPAN8 tetraspanin 8
VSNL1 visinin-like 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
AMD1 adenosylmethionine decarboxylase 1
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAMBI BMP and activin membrane-bound inhibitor
BCL10 B-cell CLL/lymphoma 10
BCL6 B-cell CLL/lymphoma 6
BCOR BCL6 corepressor
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLP1 cleavage and polyadenylation factor I subunit 1
CRIP1 cysteine-rich protein 1 (intestinal)
CXADR coxsackie virus and adenovirus receptor
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTT DNA nucleotidylexotransferase
DSP desmoplakin
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EED embryonic ectoderm development
EFNA1 ephrin-A1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM60A family with sequence similarity 60, member A
FASTKD5 FAST kinase domains 5
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
H2AFX H2A histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KLHL9 kelch-like family member 9
KLK10 kallikrein-related peptidase 10
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
MAD2L1BP MAD2L1 binding protein
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MRPL15 mitochondrial ribosomal protein L15
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTERF3 mitochondrial transcription termination factor 3
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOP56 NOP56 ribonucleoprotein
NXT1 nuclear transport factor 2-like export factor 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PODXL podocalyxin-like
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPIF peptidylprolyl isomerase F
PROM1 prominin 1
PUF60 poly-U binding splicing factor 60KDa
RAB2A RAB2A, member RAS oncogene family
RBM15 RNA binding motif protein 15
RHOB ras homolog family member B
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
SAP30 Sin3A-associated protein, 30kDa
SCGB2A1 secretoglobin, family 2A, member 1
SELL selectin L
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SNRPE small nuclear ribonucleoprotein polypeptide E
SOCS6 suppressor of cytokine signaling 6
SOX4 SRY (sex determining region Y)-box 4
TBCC tubulin folding cofactor C
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TMEM70 transmembrane protein 70
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSC22D2 TSC22 domain family, member 2
TXN thioredoxin
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217