BRD-K79090631_CGP-60474_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

364 genes differentially expressed following the BRD-K79090631_CGP-60474_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
APOM apolipoprotein M
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATRX alpha thalassemia/mental retardation syndrome X-linked
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
C2CD2 C2 calcium-dependent domain containing 2
C3 complement component 3
C5AR1 complement component 5a receptor 1
C7 complement component 7
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CCND1 cyclin D1
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CD84 CD84 molecule
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CFD complement factor D (adipsin)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN1 claudin 1
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
CLIC2 chloride intracellular channel 2
CNPY3 canopy FGF signaling regulator 3
COASY CoA synthase
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CRABP1 cellular retinoic acid binding protein 1
CST1 cystatin SN
CST3 cystatin C
CTTN cortactin
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPT dermatopontin
DSE dermatan sulfate epimerase
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
ESRP1 epithelial splicing regulatory protein 1
EVI2A ecotropic viral integration site 2A
EXPH5 exophilin 5
F11R F11 receptor
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAM171A1 family with sequence similarity 171, member A1
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FKBP14 FK506 binding protein 14, 22 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FMO1 flavin containing monooxygenase 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FYB FYN binding protein
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GPI glucose-6-phosphate isomerase
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOOK2 hook microtubule-tethering protein 2
HOXA5 homeobox A5
HOXD1 homeobox D1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
ISYNA1 inositol-3-phosphate synthase 1
ITM2C integral membrane protein 2C
KIF5C kinesin family member 5C
KNG1 kininogen 1
LAMP1 lysosomal-associated membrane protein 1
LAMP3 lysosomal-associated membrane protein 3
LGMN legumain
LOX lysyl oxidase
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC15 leucine rich repeat containing 15
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPT microtubule-associated protein tau
MBP myelin basic protein
MCOLN1 mucolipin 1
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MRPS16 mitochondrial ribosomal protein S16
MSLN mesothelin
MT1F metallothionein 1F
MX2 MX dynamin-like GTPase 2
NMU neuromedin U
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NYNRIN NYN domain and retroviral integrase containing
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARP8 poly (ADP-ribose) polymerase family, member 8
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLLP plasmolipin
PPIF peptidylprolyl isomerase F
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCB protein kinase C, beta
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PRR7 proline rich 7 (synaptic)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS21 protease, serine, 21 (testisin)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB38 RAB38, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RHOBTB3 Rho-related BTB domain containing 3
RPL31 ribosomal protein L31
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELL selectin L
SEPP1 selenoprotein P, plasma, 1
SEPT6 septin 6
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SIDT2 SID1 transmembrane family, member 2
SIRPA signal-regulatory protein alpha
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX10 sorting nexin 10
SOD2 superoxide dismutase 2, mitochondrial
SOX17 SRY (sex determining region Y)-box 17
SPEN spen family transcriptional repressor
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON1 spondin 1, extracellular matrix protein
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNGR2 synaptogyrin 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCTN1 tectonic family member 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRAPPC6A trafficking protein particle complex 6A
TRBC1 T cell receptor beta constant 1
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TSTA3 tissue specific transplantation antigen P35B
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UGT8 UDP glycosyltransferase 8
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ADGRL2 adhesion G protein-coupled receptor L2
ADI1 acireductone dioxygenase 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAMBI BMP and activin membrane-bound inhibitor
BLMH bleomycin hydrolase
BTG1 B-cell translocation gene 1, anti-proliferative
C16ORF45 chromosome 16 open reading frame 45
C3ORF14 chromosome 3 open reading frame 14
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNG2 cyclin G2
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC20 cell division cycle 20
CDK14 cyclin-dependent kinase 14
CELF2 CUGBP, Elav-like family member 2
CHMP4A charged multivesicular body protein 4A
CLTA clathrin, light chain A
COL14A1 collagen, type XIV, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYTH1 cytohesin 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPTOR DEP domain containing MTOR-interacting protein
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENSA endosulfine alpha
FABP7 fatty acid binding protein 7, brain
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GJA1 gap junction protein, alpha 1, 43kDa
GLO1 glyoxalase I
GLOD4 glyoxalase domain containing 4
GRB10 growth factor receptor-bound protein 10
GTPBP8 GTP-binding protein 8 (putative)
H2AFZ H2A histone family, member Z
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMBOX1 homeobox containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
IGSF3 immunoglobulin superfamily, member 3
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
JUP junction plakoglobin
KDM3A lysine (K)-specific demethylase 3A
KEAP1 kelch-like ECH-associated protein 1
KLHL9 kelch-like family member 9
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LDLR low density lipoprotein receptor
LRP4 low density lipoprotein receptor-related protein 4
MAPK6 mitogen-activated protein kinase 6
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MGP matrix Gla protein
MID1 midline 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
MYBPC1 myosin binding protein C, slow type
MYO10 myosin X
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDUFA4 NDUFA4, mitochondrial complex associated
NEFL neurofilament, light polypeptide
NES nestin
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCM1 pericentriolar material 1
PCNA proliferating cell nuclear antigen
PDLIM5 PDZ and LIM domain 5
PFDN4 prefoldin subunit 4
PFKP phosphofructokinase, platelet
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTN pleiotrophin
PWP1 PWP1 homolog (S. cerevisiae)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RFC2 replication factor C (activator 1) 2, 40kDa
RGS1 regulator of G-protein signaling 1
RIN2 Ras and Rab interactor 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SDC2 syndecan 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SNAP25 synaptosomal-associated protein, 25kDa
SPON2 spondin 2, extracellular matrix protein
SRSF1 serine/arginine-rich splicing factor 1
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR3 transforming growth factor, beta receptor III
THSD7A thrombospondin, type I, domain containing 7A
TMSB15A thymosin beta 15a
TNC tenascin C
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TSPYL5 TSPY-like 5
TUBA4A tubulin, alpha 4a
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP22 ubiquitin specific peptidase 22
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
WSB1 WD repeat and SOCS box containing 1
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC6 zinc finger, DHHC-type containing 6
ZIC1 Zic family member 1
ZNF302 zinc finger protein 302