BRD-K79090631_CGP-60474_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

232 genes differentially expressed following the BRD-K79090631_CGP-60474_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ADGRG6 adhesion G protein-coupled receptor G6
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
APOD apolipoprotein D
BCHE butyrylcholinesterase
C1ORF115 chromosome 1 open reading frame 115
CLGN calmegin
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL3A1 collagen, type III, alpha 1
COMP cartilage oligomeric matrix protein
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FLRT2 fibronectin leucine rich transmembrane protein 2
FZD6 frizzled class receptor 6
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
H2AFY H2A histone family, member Y
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KIF5B kinesin family member 5B
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTBP3 latent transforming growth factor beta binding protein 3
LUM lumican
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MET MET proto-oncogene, receptor tyrosine kinase
MTUS1 microtubule associated tumor suppressor 1
MXRA5 matrix-remodelling associated 5
NDN necdin, melanoma antigen (MAGE) family member
NRP1 neuropilin 1
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEX11A peroxisomal biogenesis factor 11 alpha
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RGS10 regulator of G-protein signaling 10
SATB1 SATB homeobox 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELL selectin L
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SOX11 SRY (sex determining region Y)-box 11
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMSB15A thymosin beta 15a
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
VWA5A von Willebrand factor A domain containing 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL10 B-cell CLL/lymphoma 10
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1ORF106 chromosome 1 open reading frame 106
CA2 carbonic anhydrase II
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CCNF cyclin F
CCNL1 cyclin L1
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CLP1 cleavage and polyadenylation factor I subunit 1
CRABP1 cellular retinoic acid binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFA4 defensin, alpha 4, corticostatin
DEFB1 defensin, beta 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
ELANE elastase, neutrophil expressed
ELF4 E74-like factor 4 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM60A family with sequence similarity 60, member A
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FEM1C fem-1 homolog c (C. elegans)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAREM GRB2 associated, regulator of MAPK1
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ITPKC inositol-trisphosphate 3-kinase C
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LMNA lamin A/C
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MID1IP1 MID1 interacting protein 1
MIR22HG MIR22 host gene
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NUP153 nucleoporin 153kDa
NXT1 nuclear transport factor 2-like export factor 1
OSER1 oxidative stress responsive serine-rich 1
PDGFA platelet-derived growth factor alpha polypeptide
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAGL2 pleiomorphic adenoma gene-like 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRTN3 proteinase 3
PTX3 pentraxin 3, long
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RYBP RING1 and YY1 binding protein
SDC4 syndecan 4
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SERTAD3 SERTA domain containing 3
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VEZF1 vascular endothelial zinc finger 1
WEE1 WEE1 G2 checkpoint kinase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
ZNF24 zinc finger protein 24
ZNF281 zinc finger protein 281