BRD-K79090631_CGP-60474_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

270 genes differentially expressed following the BRD-K79090631_CGP-60474_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ACOT7 acyl-CoA thioesterase 7
ADAMDEC1 ADAM-like, decysin 1
ADCY7 adenylate cyclase 7
ADD3 adducin 3 (gamma)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANO1 anoctamin 1, calcium activated chloride channel
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BLNK B-cell linker
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BTG2 BTG family, member 2
C2 complement component 2
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CD2 CD2 molecule
CD4 CD4 molecule
CD84 CD84 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CFD complement factor D (adipsin)
CLEC7A C-type lectin domain family 7, member A
CLIC2 chloride intracellular channel 2
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CREBL2 cAMP responsive element binding protein-like 2
CRP C-reactive protein, pentraxin-related
CTSB cathepsin B
CTSC cathepsin C
CTSZ cathepsin Z
CTTN cortactin
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYB561 cytochrome b561
CYB5A cytochrome b5 type A (microsomal)
CYBB cytochrome b-245, beta polypeptide
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
E2F2 E2F transcription factor 2
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
EXPH5 exophilin 5
FBLN1 fibulin 1
FECH ferrochelatase
FLRT2 fibronectin leucine rich transmembrane protein 2
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF1 forkhead box F1
FRY furry homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
FYB FYN binding protein
FZD6 frizzled class receptor 6
GADD45B growth arrest and DNA-damage-inducible, beta
GALNS galactosamine (N-acetyl)-6-sulfatase
GFOD1 glucose-fructose oxidoreductase domain containing 1
GNS glucosamine (N-acetyl)-6-sulfatase
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUK1 guanylate kinase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN5 high mobility group nucleosome binding domain 5
HRG histidine-rich glycoprotein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
ISG15 ISG15 ubiquitin-like modifier
ITFG1 integrin alpha FG-GAP repeat containing 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUNB jun B proto-oncogene
KNG1 kininogen 1
LAMP3 lysosomal-associated membrane protein 3
LGMN legumain
LPPR4 lipid phosphate phosphatase-related protein type 4
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRRC17 leucine rich repeat containing 17
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP1 latent transforming growth factor beta binding protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN2B2 mannosidase, alpha, class 2B, member 2
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
NGRN neugrin, neurite outgrowth associated
NMU neuromedin U
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
OVGP1 oviductal glycoprotein 1, 120kDa
PCBP2 poly(rC) binding protein 2
PLBD1 phospholipase B domain containing 1
PLD3 phospholipase D family, member 3
PPT1 palmitoyl-protein thioesterase 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROS1 protein S (alpha)
PRSS21 protease, serine, 21 (testisin)
PTCH1 patched 1
PTPRD protein tyrosine phosphatase, receptor type, D
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RTN3 reticulon 3
S100A4 S100 calcium binding protein A4
SCD5 stearoyl-CoA desaturase 5
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SH2D1A SH2 domain containing 1A
SH3BGRL SH3 domain binding glutamate-rich protein like
SHANK2 SH3 and multiple ankyrin repeat domains 2
SNX10 sorting nexin 10
STC1 stanniocalcin 1
STMN2 stathmin 2
SYNGR2 synaptogyrin 2
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TKTL1 transketolase-like 1
TMEM14B transmembrane protein 14B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TPMT thiopurine S-methyltransferase
TPP1 tripeptidyl peptidase I
TRBC1 T cell receptor beta constant 1
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BUB3 BUB3 mitotic checkpoint protein
CAB39 calcium binding protein 39
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPA centromere protein A
CLTA clathrin, light chain A
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSE1L CSE1 chromosome segregation 1-like (yeast)
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EAPP E2F-associated phosphoprotein
EIF6 eukaryotic translation initiation factor 6
ETV5 ets variant 5
FABP7 fatty acid binding protein 7, brain
FHL2 four and a half LIM domains 2
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GLOD4 glyoxalase domain containing 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IL1R2 interleukin 1 receptor, type II
INHBB inhibin, beta B
IVNS1ABP influenza virus NS1A binding protein
JMJD6 jumonji domain containing 6
KIF20A kinesin family member 20A
KLK5 kallikrein-related peptidase 5
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT15 keratin 15, type I
LBR lamin B receptor
LTF lactotransferrin
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRPS12 mitochondrial ribosomal protein S12
MYBPC1 myosin binding protein C, slow type
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PCM1 pericentriolar material 1
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PHC2 polyhomeotic homolog 2 (Drosophila)
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PNN pinin, desmosome associated protein
PNP purine nucleoside phosphorylase
POSTN periostin, osteoblast specific factor
PSD3 pleckstrin and Sec7 domain containing 3
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
PXDN peroxidasin
RAE1 ribonucleic acid export 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC38A2 solute carrier family 38, member 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPX2 TPX2, microtubule-associated
TRAM2 translocation associated membrane protein 2
TRIM29 tripartite motif containing 29
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
VCAN versican
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
ZDHHC6 zinc finger, DHHC-type containing 6