BRD-K79090631_CGP-60474_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

274 genes differentially expressed following the BRD-K79090631_CGP-60474_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADGRG2 adhesion G protein-coupled receptor G2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIF1 allograft inflammatory factor 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD10 ankyrin repeat domain 10
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
AQP9 aquaporin 9
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
BHMT2 betaine--homocysteine S-methyltransferase 2
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C5AR1 complement component 5a receptor 1
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFB complement factor B
CKB creatine kinase, brain
CLEC7A C-type lectin domain family 7, member A
CLGN calmegin
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSS cathepsin S
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP2 cytoplasmic FMR1 interacting protein 2
DACH1 dachshund family transcription factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DPH2 DPH2 homolog (S. cerevisiae)
DST dystonin
DUSP2 dual specificity phosphatase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMX2 empty spiracles homeobox 2
ENO2 enolase 2 (gamma, neuronal)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM13A family with sequence similarity 13, member A
FAM162A family with sequence similarity 162, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GCA grancalcin, EF-hand calcium binding protein
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
GUSBP3 glucuronidase, beta pseudogene 3
HEBP1 heme binding protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
IDS iduronate 2-sulfatase
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IL10RA interleukin 10 receptor, alpha
ITGB7 integrin, beta 7
KDM5D lysine (K)-specific demethylase 5D
LOX lysyl oxidase
LTBP1 latent transforming growth factor beta binding protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MATN2 matrilin 2
MBP myelin basic protein
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MDFIC MyoD family inhibitor domain containing
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCBP2 poly(rC) binding protein 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PGK1 phosphoglycerate kinase 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKCB protein kinase C, beta
PSPH phosphoserine phosphatase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
REEP5 receptor accessory protein 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RORA RAR-related orphan receptor A
RPS4Y1 ribosomal protein S4, Y-linked 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMYD3 SET and MYND domain containing 3
SPINK1 serine peptidase inhibitor, Kazal type 1
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYBU syntabulin (syntaxin-interacting)
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
THBS4 thrombospondin 4
THY1 Thy-1 cell surface antigen
TICAM1 toll-like receptor adaptor molecule 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TREM1 triggering receptor expressed on myeloid cells 1
TYROBP TYRO protein tyrosine kinase binding protein
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI
VIM vimentin
ZBTB18 zinc finger and BTB domain containing 18
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AIM1 absent in melanoma 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
ATG3 autophagy related 3
ATMIN ATM interactor
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AURKA aurora kinase A
C2CD5 C2 calcium-dependent domain containing 5
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CD200 CD200 molecule
CD58 CD58 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLTA clathrin, light chain A
CTBP2 C-terminal binding protein 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
EED embryonic ectoderm development
ERBB2 erb-b2 receptor tyrosine kinase 2
FA2H fatty acid 2-hydroxylase
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
H2AFX H2A histone family, member X
HEBP2 heme binding protein 2
HLF hepatic leukemia factor
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB7 homeobox B7
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IGSF3 immunoglobulin superfamily, member 3
IL6ST interleukin 6 signal transducer
KAZN kazrin, periplakin interacting protein
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIF20A kinesin family member 20A
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT4 keratin 4, type II
KRT7 keratin 7, type II
LAD1 ladinin 1
LBR lamin B receptor
LGALS1 lectin, galactoside-binding, soluble, 1
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MAPK13 mitogen-activated protein kinase 13
MEIS2 Meis homeobox 2
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
NEK2 NIMA-related kinase 2
NLRP2 NLR family, pyrin domain containing 2
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NRP1 neuropilin 1
NUSAP1 nucleolar and spindle associated protein 1
OAT ornithine aminotransferase
PCNA proliferating cell nuclear antigen
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP prolactin-induced protein
PLK1 polo-like kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PRC1 protein regulator of cytokinesis 1
PRKCD protein kinase C, delta
PROM1 prominin 1
PSCA prostate stem cell antigen
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTTG1 pituitary tumor-transforming 1
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNPS1 RNA binding protein S1, serine-rich domain
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC25A46 solute carrier family 25, member 46
SMC4 structural maintenance of chromosomes 4
SPP1 secreted phosphoprotein 1
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STMN1 stathmin 1
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TF transferrin
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE4 transducin-like enhancer of split 4
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TTK TTK protein kinase
TUBB4B tubulin, beta 4B class IVb
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
XIST X inactive specific transcript (non-protein coding)