BRD-K79018442_KIN001-260;_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K79018442_KIN001-260;_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BZW2 basic leucine zipper and W2 domains 2
CLEC2B C-type lectin domain family 2, member B
CP ceruloplasmin (ferroxidase)
CST6 cystatin E/M
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR1 early growth response 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP7 fatty acid binding protein 7, brain
FASN fatty acid synthase
FGFR4 fibroblast growth factor receptor 4
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GSTA4 glutathione S-transferase alpha 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
KYNU kynureninase
LAPTM4B lysosomal protein transmembrane 4 beta
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MPZL2 myelin protein zero-like 2
MSMO1 methylsterol monooxygenase 1
MXRA5 matrix-remodelling associated 5
NEBL nebulette
NPC2 Niemann-Pick disease, type C2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
PDLIM1 PDZ and LIM domain 1
SC5D sterol-C5-desaturase
SFTPB surfactant protein B
SFTPC surfactant protein C
SFTPD surfactant protein D
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SQSTM1 sequestosome 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSPAN13 tetraspanin 13
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
BASP1 brain abundant, membrane attached signal protein 1
CA12 carbonic anhydrase XII
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSE dermatan sulfate epimerase
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FABP4 fatty acid binding protein 4, adipocyte
G0S2 G0/G1 switch 2
GJA1 gap junction protein, alpha 1, 43kDa
IGF1R insulin-like growth factor 1 receptor
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
LYZ lysozyme
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MARCKS myristoylated alanine-rich protein kinase C substrate
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NGRN neugrin, neurite outgrowth associated
PCNA proliferating cell nuclear antigen
PDGFC platelet derived growth factor C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSD3 pleckstrin and Sec7 domain containing 3
RBM47 RNA binding motif protein 47
SRGN serglycin
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TM9SF3 transmembrane 9 superfamily member 3
TYMS thymidylate synthetase