BRD-K78867378_mw-A1-12_DV90_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K78867378_mw-A1-12_DV90_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
BAG3 BCL2-associated athanogene 3
BPHL biphenyl hydrolase-like (serine hydrolase)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CLDN3 claudin 3
COL5A2 collagen, type V, alpha 2
CTGF connective tissue growth factor
CUX1 cut-like homeobox 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DLC1 DLC1 Rho GTPase activating protein
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
EIF5A eukaryotic translation initiation factor 5A
ETV1 ets variant 1
FGL2 fibrinogen-like 2
FXYD6 FXYD domain containing ion transport regulator 6
GADD45B growth arrest and DNA-damage-inducible, beta
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GREB1 growth regulation by estrogen in breast cancer 1
HEBP2 heme binding protein 2
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
INHBA inhibin, beta A
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KDM5B lysine (K)-specific demethylase 5B
NOX4 NADPH oxidase 4
PCP4 Purkinje cell protein 4
PEG3 paternally expressed 3
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
SFRP4 secreted frizzled-related protein 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS2 suppressor of cytokine signaling 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
STON1 stonin 1
SULF1 sulfatase 1
TBX3 T-box 3
TCF21 transcription factor 21
THBS1 thrombospondin 1
TLE2 transducin-like enhancer of split 2
TMSB15A thymosin beta 15a
TSC22D1 TSC22 domain family, member 1
WT1 Wilms tumor 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF131 zinc finger protein 131
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM8 ADAM metallopeptidase domain 8
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
AQP3 aquaporin 3 (Gill blood group)
B3GNT1
BIRC3 baculoviral IAP repeat containing 3
CA12 carbonic anhydrase XII
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD59 CD59 molecule, complement regulatory protein
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLEC3B C-type lectin domain family 3, member B
CTSH cathepsin H
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DKC1 dyskeratosis congenita 1, dyskerin
ECM1 extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAR2 fatty acyl CoA reductase 2
FCGBP Fc fragment of IgG binding protein
FST follistatin
FZD7 frizzled class receptor 7
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
HEATR1 HEAT repeat containing 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
LPAR1 lysophosphatidic acid receptor 1
LPL lipoprotein lipase
LY75 lymphocyte antigen 75
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MMP7 matrix metallopeptidase 7
MNAT1 MNAT CDK-activating kinase assembly factor 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
PI3 peptidase inhibitor 3, skin-derived
PLAC8 placenta-specific 8
PLTP phospholipid transfer protein
PNMA2 paraneoplastic Ma antigen 2
PRSS2 protease, serine, 2 (trypsin 2)
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGS1 regulator of G-protein signaling 1
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SPINK1 serine peptidase inhibitor, Kazal type 1
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSPAN3 tetraspanin 3
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1