BRD-K78659596_MLN2238_SKMEL1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K78659596_MLN2238_SKMEL1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZU1 azurocidin 1
BAG3 BCL2-associated athanogene 3
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
CRABP2 cellular retinoic acid binding protein 2
CSRP1 cysteine and glycine-rich protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DSC2 desmocollin 2
EIF5A eukaryotic translation initiation factor 5A
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
GCLM glutamate-cysteine ligase, modifier subunit
GUSBP11 glucuronidase, beta pseudogene 11
HEBP2 heme binding protein 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JCHAIN joining chain of multimeric IgA and IgM
LAPTM5 lysosomal protein transmembrane 5
MBTPS1 membrane-bound transcription factor peptidase, site 1
MFSD10 major facilitator superfamily domain containing 10
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1X metallothionein 1X
OLFM4 olfactomedin 4
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POU2AF1 POU class 2 associating factor 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFTPB surfactant protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIRT3 sirtuin 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
STX18 syntaxin 18
TACSTD2 tumor-associated calcium signal transducer 2
THBS4 thrombospondin 4
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TRPS1 trichorhinophalangeal syndrome I
TUSC3 tumor suppressor candidate 3
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
ACE2 angiotensin I converting enzyme 2
AHNAK2 AHNAK nucleoprotein 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMZ2 archaelysin family metallopeptidase 2
AOX1 aldehyde oxidase 1
AREG amphiregulin
ASPH aspartate beta-hydroxylase
BEX1 brain expressed, X-linked 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND1 cyclin D1
CD24 CD24 molecule
CD34 CD34 molecule
CDC20 cell division cycle 20
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CST1 cystatin SN
CTSV cathepsin V
CXCL3 chemokine (C-X-C motif) ligand 3
DCT dopachrome tautomerase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EDNRB endothelin receptor type B
ELF1 E74-like factor 1 (ets domain transcription factor)
FHL1 four and a half LIM domains 1
FOXN3 forkhead box N3
FXYD2 FXYD domain containing ion transport regulator 2
FXYD3 FXYD domain containing ion transport regulator 3
GLDC glycine dehydrogenase (decarboxylating)
GPX2 glutathione peroxidase 2
GTF3A general transcription factor IIIA
HDAC9 histone deacetylase 9
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB7 homeobox B7
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ITGA6 integrin, alpha 6
IVNS1ABP influenza virus NS1A binding protein
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KANK2 KN motif and ankyrin repeat domains 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT20 keratin 20, type I
KRT23 keratin 23, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC100505650 uncharacterized LOC100505650
MACF1 microtubule-actin crosslinking factor 1
MGLL monoglyceride lipase
MLANA melan-A
MLEC malectin
MLPH melanophilin
MSH6 mutS homolog 6
MTSS1 metastasis suppressor 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOV nephroblastoma overexpressed
NTS neurotensin
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDZRN3 PDZ domain containing ring finger 3
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLCB4 phospholipase C, beta 4
PLN phospholamban
PMEL premelanosome protein
PNMA2 paraneoplastic Ma antigen 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RELN reelin
RHOQ ras homolog family member Q
RNASEH2A ribonuclease H2, subunit A
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTBN1 spectrin, beta, non-erythrocytic 1
TBX2 T-box 2
TCF4 transcription factor 4
TCTA T-cell leukemia translocation altered
TFF1 trefoil factor 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM251 transmembrane protein 251
TMEM47 transmembrane protein 47
TMEM5 transmembrane protein 5
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TSC22D1 TSC22 domain family, member 1
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
TYRP1 tyrosinase-related protein 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28