BRD-K78659596_MLN2238_HEC108_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K78659596_MLN2238_HEC108_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE41 basic helix-loop-helix family, member e41
C1QA complement component 1, q subcomponent, A chain
CADM1 cell adhesion molecule 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DDIT3 DNA-damage-inducible transcript 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EAF2 ELL associated factor 2
ELN elastin
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
JUNB jun B proto-oncogene
KLK6 kallikrein-related peptidase 6
KRT6A keratin 6A, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MOXD1 monooxygenase, DBH-like 1
MSX1 msh homeobox 1
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
MYH10 myosin, heavy chain 10, non-muscle
NEB nebulin
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
POPDC3 popeye domain containing 3
POU2AF1 POU class 2 associating factor 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAE1 ribonucleic acid export 1
RIOK3 RIO kinase 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX11 sorting nexin 11
SPP1 secreted phosphoprotein 1
TARS threonyl-tRNA synthetase
TXNRD1 thioredoxin reductase 1
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
ZNF394 zinc finger protein 394
ZNF451 zinc finger protein 451
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ALOX5 arachidonate 5-lipoxygenase
APMAP adipocyte plasma membrane associated protein
AREG amphiregulin
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPH aspartate beta-hydroxylase
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B3GNT1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CAV1 caveolin 1, caveolae protein, 22kDa
CBX5 chromobox homolog 5
CCNB2 cyclin B2
CCND2 cyclin D2
CCNF cyclin F
CDC25B cell division cycle 25B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRIP2 cysteine-rich protein 2
CTSC cathepsin C
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EFHD1 EF-hand domain family, member D1
EGR3 early growth response 3
ELOVL6 ELOVL fatty acid elongase 6
EMP3 epithelial membrane protein 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM162A family with sequence similarity 162, member A
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSTM3 glutathione S-transferase mu 3 (brain)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H4C histone cluster 1, H4c
HOXA10 homeobox A10
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
ISG15 ISG15 ubiquitin-like modifier
KANK2 KN motif and ankyrin repeat domains 2
KIAA0485 uncharacterized LOC57235
KRT1 keratin 1, type II
LAMB1 laminin, beta 1
LIN28A lin-28 homolog A (C. elegans)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTB lymphotoxin beta (TNF superfamily, member 3)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAN1A1 mannosidase, alpha, class 1A, member 1
MRPL57 mitochondrial ribosomal protein L57
NEK2 NIMA-related kinase 2
NPC2 Niemann-Pick disease, type C2
NPY1R neuropeptide Y receptor Y1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
PBLD phenazine biosynthesis-like protein domain containing
PCCA propionyl CoA carboxylase, alpha polypeptide
PGAM1 phosphoglycerate mutase 1 (brain)
PLA2G16 phospholipase A2, group XVI
PROM1 prominin 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTMA prothymosin, alpha
PTPRC protein tyrosine phosphatase, receptor type, C
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAP2C RAP2C, member of RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM47 RNA binding motif protein 47
RBPMS RNA binding protein with multiple splicing
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SCAND1 SCAN domain containing 1
SELENBP1 selenium binding protein 1
SFRP1 secreted frizzled-related protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THY1 Thy-1 cell surface antigen
TMEM45A transmembrane protein 45A
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN12 tetraspanin 12
TSPAN4 tetraspanin 4
UBE2C ubiquitin-conjugating enzyme E2C
ZBTB18 zinc finger and BTB domain containing 18