BRD-K78431006_crizotinib_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K78431006_crizotinib_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AQP9 aquaporin 9
AREG amphiregulin
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
C5AR1 complement component 5a receptor 1
CA12 carbonic anhydrase XII
CLU clusterin
CST3 cystatin C
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
FPR1 formyl peptide receptor 1
GSTK1 glutathione S-transferase kappa 1
LEPR leptin receptor
LTF lactotransferrin
MET MET proto-oncogene, receptor tyrosine kinase
NAV3 neuron navigator 3
NR2F1 nuclear receptor subfamily 2, group F, member 1
PKN2 protein kinase N2
PLK2 polo-like kinase 2
PPID peptidylprolyl isomerase D
PTGDS prostaglandin D2 synthase 21kDa (brain)
RELN reelin
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
TBX2 T-box 2
TGIF1 TGFB-induced factor homeobox 1
THAP11 THAP domain containing 11
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TPM4 tropomyosin 4
VCAN versican
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACPP acid phosphatase, prostate
AKAP13 A kinase (PRKA) anchor protein 13
AQP3 aquaporin 3 (Gill blood group)
C8ORF4 chromosome 8 open reading frame 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHN1 chimerin 1
CLEC2B C-type lectin domain family 2, member B
COG7 component of oligomeric golgi complex 7
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPYSL3 dihydropyrimidinase-like 3
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
LAPTM4B lysosomal protein transmembrane 4 beta
LPCAT1 lysophosphatidylcholine acyltransferase 1
MALL mal, T-cell differentiation protein-like
MFAP2 microfibrillar-associated protein 2
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MSMB microseminoprotein, beta-
MTERF3 mitochondrial transcription termination factor 3
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NLRP2 NLR family, pyrin domain containing 2
NQO2 NAD(P)H dehydrogenase, quinone 2
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PROM1 prominin 1
SRPX sushi-repeat containing protein, X-linked
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
WWTR1 WW domain containing transcription regulator 1
ZW10 zw10 kinetochore protein