BRD-K78431006_crizotinib_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K78431006_crizotinib_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOC1 apolipoprotein C-I
ARG2 arginase 2
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD8A CD8a molecule
CHN2 chimerin 2
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
CP ceruloplasmin (ferroxidase)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DUOX2 dual oxidase 2
DUSP10 dual specificity phosphatase 10
EPHB2 EPH receptor B2
FAM57A family with sequence similarity 57, member A
FOSL2 FOS-like antigen 2
GUSBP11 glucuronidase, beta pseudogene 11
HLA-DMA major histocompatibility complex, class II, DM alpha
IGHM immunoglobulin heavy constant mu
IGKV3-20 immunoglobulin kappa variable 3-20
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
ITGAV integrin, alpha V
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LAPTM5 lysosomal protein transmembrane 5
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K5 mitogen-activated protein kinase kinase 5
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
MYRF myelin regulatory factor
NAV3 neuron navigator 3
NR4A3 nuclear receptor subfamily 4, group A, member 3
PDZK1IP1 PDZK1 interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REG1A regenerating islet-derived 1 alpha
REG1B regenerating islet-derived 1 beta
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIK1 salt-inducible kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SPP1 secreted phosphoprotein 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TGFBI transforming growth factor, beta-induced, 68kDa
THSD7A thrombospondin, type I, domain containing 7A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AK4 adenylate kinase 4
ANXA1 annexin A1
AREG amphiregulin
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
HBB hemoglobin, beta
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
LAPTM4A lysosomal protein transmembrane 4 alpha
LOC100505650 uncharacterized LOC100505650
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PTHLH parathyroid hormone-like hormone
SDC4 syndecan 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
TACSTD2 tumor-associated calcium signal transducer 2