BRD-K78431006_crizotinib_BT20_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K78431006_crizotinib_BT20_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRLF1 cytokine receptor-like factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMXL2 Dmx-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAS Fas cell surface death receptor
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GRWD1 glutamate-rich WD repeat containing 1
GSTT1 glutathione S-transferase theta 1
JCHAIN joining chain of multimeric IgA and IgM
KDM5D lysine (K)-specific demethylase 5D
KRT19 keratin 19, type I
LGALS3 lectin, galactoside-binding, soluble, 3
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
OPN3 opsin 3
RBM15B RNA binding motif protein 15B
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SMAD7 SMAD family member 7
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
TBL1X transducin (beta)-like 1X-linked
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPST2 tyrosylprotein sulfotransferase 2
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ANXA3 annexin A3
C6ORF62 chromosome 6 open reading frame 62
CCNE2 cyclin E2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL3A1 collagen, type III, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
EIF5 eukaryotic translation initiation factor 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FBN1 fibrillin 1
FCGBP Fc fragment of IgG binding protein
GAL galanin/GMAP prepropeptide
GAS1 growth arrest-specific 1
GPM6B glycoprotein M6B
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HOXC6 homeobox C6
HSPA2 heat shock 70kDa protein 2
LPAR1 lysophosphatidic acid receptor 1
MAB21L2 mab-21-like 2 (C. elegans)
MAPT microtubule-associated protein tau
MATN2 matrilin 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLAC8 placenta-specific 8
PLP1 proteolipid protein 1
RGS5 regulator of G-protein signaling 5
RPS11 ribosomal protein S11
SYT1 synaptotagmin I
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TUBB2B tubulin, beta 2B class IIb
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon