BRD-K78431006_HY-50878_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-K78431006_HY-50878_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C1RL complement component 1, r subcomponent-like
CAPG capping protein (actin filament), gelsolin-like
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCNG2 cyclin G2
CD52 CD52 molecule
CDK19 cyclin-dependent kinase 19
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CLIC4 chloride intracellular channel 4
CTSS cathepsin S
EPAS1 endothelial PAS domain protein 1
EZR ezrin
FAM129A family with sequence similarity 129, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBP1 fructose-1,6-bisphosphatase 1
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FSD1 fibronectin type III and SPRY domain containing 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLRX glutaredoxin (thioltransferase)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL32 interleukin 32
JCHAIN joining chain of multimeric IgA and IgM
LPIN1 lipin 1
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MSN moesin
MYO6 myosin VI
NBPF10 neuroblastoma breakpoint family, member 10
NEBL nebulette
PERP PERP, TP53 apoptosis effector
PIEZO2 piezo-type mechanosensitive ion channel component 2
PPAP2B phosphatidic acid phosphatase type 2B
PXDN peroxidasin
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A10 S100 calcium binding protein A10
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SKAP2 src kinase associated phosphoprotein 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
TAPBP TAP binding protein (tapasin)
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBC1D31 TBC1 domain family, member 31
TF transferrin
TPP1 tripeptidyl peptidase I
TSPAN5 tetraspanin 5
VAT1 vesicle amine transport 1
WNT5A wingless-type MMTV integration site family, member 5A
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18
ZYX zyxin

decreased expression

Symbol Name
ADSL adenylosuccinate lyase
AHCY adenosylhomocysteinase
ANAPC5 anaphase promoting complex subunit 5
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
BOP1 block of proliferation 1
BST2 bone marrow stromal cell antigen 2
C1QBP complement component 1, q subcomponent binding protein
CCDC85B coiled-coil domain containing 85B
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDK4 cyclin-dependent kinase 4
CENPU centromere protein U
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLGA4 golgin A4
HELLS helicase, lymphoid-specific
HLTF helicase-like transcription factor
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS isoleucyl-tRNA synthetase
ICMT isoprenylcysteine carboxyl methyltransferase
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MBNL1 muscleblind-like splicing regulator 1
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MRPL20 mitochondrial ribosomal protein L20
MRPS16 mitochondrial ribosomal protein S16
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUP62 nucleoporin 62kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PRDX4 peroxiredoxin 4
PRR7 proline rich 7 (synaptic)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAN RAN, member RAS oncogene family
RBM3 RNA binding motif (RNP1, RRM) protein 3
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA1 replication protein A1, 70kDa
RPL22 ribosomal protein L22
RPL36 ribosomal protein L36
RPL4 ribosomal protein L4
RPS21 ribosomal protein S21
RRM2 ribonucleotide reductase M2
SEH1L SEH1-like (S. cerevisiae)
SLIRP SRA stem-loop interacting RNA binding protein
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAM transcription factor A, mitochondrial
TMED3 transmembrane emp24 protein transport domain containing 3
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TMX4 thioredoxin-related transmembrane protein 4
UBA2 ubiquitin-like modifier activating enzyme 2
ZWINT ZW10 interacting kinetochore protein