BRD-K78431006_HY-50878_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K78431006_HY-50878_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AQP1 aquaporin 1 (Colton blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BNC2 basonuclin 2
CAV1 caveolin 1, caveolae protein, 22kDa
CD99 CD99 molecule
CFB complement factor B
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
CLIC4 chloride intracellular channel 4
COL14A1 collagen, type XIV, alpha 1
CPD carboxypeptidase D
CREM cAMP responsive element modulator
CTSS cathepsin S
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
FASN fatty acid synthase
G0S2 G0/G1 switch 2
GATA3 GATA binding protein 3
GPNMB glycoprotein (transmembrane) nmb
GPR183 G protein-coupled receptor 183
GREM1 gremlin 1, DAN family BMP antagonist
GSTA1 glutathione S-transferase alpha 1
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HPSE heparanase
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLF6 Kruppel-like factor 6
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS8 lectin, galactoside-binding, soluble, 8
LUM lumican
MFAP2 microfibrillar-associated protein 2
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OLFML2A olfactomedin-like 2A
PBX3 pre-B-cell leukemia homeobox 3
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRL platelet-derived growth factor receptor-like
PNRC1 proline-rich nuclear receptor coactivator 1
PRTN3 proteinase 3
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD23B RAD23 homolog B (S. cerevisiae)
RPP38 ribonuclease P/MRP 38kDa subunit
S100A9 S100 calcium binding protein A9
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIK3 SIK family kinase 3
SNRK SNF related kinase
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMPRSS3 transmembrane protease, serine 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TXNIP thioredoxin interacting protein
UBE2H ubiquitin-conjugating enzyme E2H
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VGLL1 vestigial-like family member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZNF131 zinc finger protein 131
ZNF331 zinc finger protein 331
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD2 abhydrolase domain containing 2
ACTC1 actin, alpha, cardiac muscle 1
ADARB1 adenosine deaminase, RNA-specific, B1
ADCY1 adenylate cyclase 1 (brain)
AKAP11 A kinase (PRKA) anchor protein 11
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP3 aquaporin 3 (Gill blood group)
ARMCX6 armadillo repeat containing, X-linked 6
BRCA1 breast cancer 1, early onset
C2CD5 C2 calcium-dependent domain containing 5
CD58 CD58 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EPS15 epidermal growth factor receptor pathway substrate 15
EXOSC8 exosome component 8
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM57A family with sequence similarity 57, member A
FANCL Fanconi anemia, complementation group L
GLIPR1 GLI pathogenesis-related 1
GTF3A general transcription factor IIIA
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IL17RB interleukin 17 receptor B
KDM5D lysine (K)-specific demethylase 5D
LBR lamin B receptor
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUC7L3 LUC7-like 3 (S. cerevisiae)
LY75 lymphocyte antigen 75
MAT2A methionine adenosyltransferase II, alpha
METTL3 methyltransferase like 3
MGLL monoglyceride lipase
MID1 midline 1
MPZL1 myelin protein zero-like 1
MRPL57 mitochondrial ribosomal protein L57
MSLN mesothelin
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDS5A PDS5 cohesin associated factor A
PEX11A peroxisomal biogenesis factor 11 alpha
PLA1A phospholipase A1 member A
PLAT plasminogen activator, tissue
POLB polymerase (DNA directed), beta
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRR7 proline rich 7 (synaptic)
PYGB phosphorylase, glycogen; brain
RFC4 replication factor C (activator 1) 4, 37kDa
SAMD4A sterile alpha motif domain containing 4A
SEH1L SEH1-like (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC38A6 solute carrier family 38, member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SYT17 synaptotagmin XVII
TARDBP TAR DNA binding protein
TBP TATA box binding protein
TFRC transferrin receptor
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM5 transmembrane protein 5
TMPRSS2 transmembrane protease, serine 2
TXLNA taxilin alpha
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UFM1 ubiquitin-fold modifier 1
ZMYM2 zinc finger, MYM-type 2