BRD-K78385490_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K78385490_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ALDOC aldolase C, fructose-bisphosphate
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CD40 CD40 molecule, TNF receptor superfamily member 5
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CLEC11A C-type lectin domain family 11, member A
COL11A1 collagen, type XI, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL6A2 collagen, type VI, alpha 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
ENO2 enolase 2 (gamma, neuronal)
FBN1 fibrillin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GOLGA8A golgin A8 family, member A
GSTT1 glutathione S-transferase theta 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP5 insulin-like growth factor binding protein 5
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MMP1 matrix metallopeptidase 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NID2 nidogen 2 (osteonidogen)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PTGIS prostaglandin I2 (prostacyclin) synthase
RGCC regulator of cell cycle
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPON1 spondin 1, extracellular matrix protein
SULF1 sulfatase 1
TMEM123 transmembrane protein 123
TSC22D3 TSC22 domain family, member 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX1 armadillo repeat containing, X-linked 1
ATF5 activating transcription factor 5
CANT1 calcium activated nucleotidase 1
CDC20 cell division cycle 20
CKS2 CDC28 protein kinase regulatory subunit 2
COCH cochlin
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYB561 cytochrome b561
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPRT1 hypoxanthine phosphoribosyltransferase 1
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
NDFIP1 Nedd4 family interacting protein 1
PLK1 polo-like kinase 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRC1 protein regulator of cytokinesis 1
RET ret proto-oncogene
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SUB1 SUB1 homolog (S. cerevisiae)
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa