BRD-K78167523_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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68 genes differentially expressed following the BRD-K78167523_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CD48 CD48 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLIC3 chloride intracellular channel 3
CLU clusterin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBN2 fibrillin 2
IL1RN interleukin 1 receptor antagonist
KDM5B lysine (K)-specific demethylase 5B
MCUR1 mitochondrial calcium uniporter regulator 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NAMPT nicotinamide phosphoribosyltransferase
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NREP neuronal regeneration related protein
NUMA1 nuclear mitotic apparatus protein 1
PLAC8 placenta-specific 8
RPL31 ribosomal protein L31
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A2 S100 calcium binding protein A2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIK1 salt-inducible kinase 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF6 serine/arginine-rich splicing factor 6
TMEM14A transmembrane protein 14A
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACACB acetyl-CoA carboxylase beta
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
AREG amphiregulin
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
CIRBP cold inducible RNA binding protein
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
DPYSL2 dihydropyrimidinase-like 2
FBXO21 F-box protein 21
FZD6 frizzled class receptor 6
GARS glycyl-tRNA synthetase
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HEBP1 heme binding protein 1
HIST1H2BC histone cluster 1, H2bc
IGFBP5 insulin-like growth factor binding protein 5
IL6ST interleukin 6 signal transducer
INSR insulin receptor
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
NET1 neuroepithelial cell transforming 1
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
PCDH9 protocadherin 9
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
S100P S100 calcium binding protein P
SERINC5 serine incorporator 5
SLBP stem-loop binding protein
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM30B transmembrane protein 30B
USP22 ubiquitin specific peptidase 22