BRD-K78126613_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K78126613_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AREG amphiregulin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
F11R F11 receptor
FCMR Fc fragment of IgM receptor
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
IPO13 importin 13
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KLHL24 kelch-like family member 24
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MDK midkine (neurite growth-promoting factor 2)
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NIT1 nitrilase 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RAB20 RAB20, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SESN1 sestrin 1
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
TBX3 T-box 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
THBD thrombomodulin
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRAF5 TNF receptor-associated factor 5
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
ZFP36 ZFP36 ring finger protein
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AKAP7 A kinase (PRKA) anchor protein 7
B3GNT1
BCHE butyrylcholinesterase
BMI1 BMI1 proto-oncogene, polycomb ring finger
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAST calpastatin
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CLINT1 clathrin interactor 1
COL3A1 collagen, type III, alpha 1
CRISP3 cysteine-rich secretory protein 3
CTSG cathepsin G
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
HLTF helicase-like transcription factor
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KRT6A keratin 6A, type II
MARCKS myristoylated alanine-rich protein kinase C substrate
NFIB nuclear factor I/B
PDZK1 PDZ domain containing 1
PI3 peptidase inhibitor 3, skin-derived
PITX1 paired-like homeodomain 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSPH phosphoserine phosphatase
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SET SET nuclear proto-oncogene
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR2B small proline-rich protein 2B
TSPYL4 TSPY-like 4
TYRP1 tyrosinase-related protein 1
ZNF185 zinc finger protein 185 (LIM domain)