BRD-K78126613_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K78126613_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
APOC1 apolipoprotein C-I
ARMCX6 armadillo repeat containing, X-linked 6
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
CD48 CD48 molecule
CD9 CD9 molecule
CKS2 CDC28 protein kinase regulatory subunit 2
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GLA galactosidase, alpha
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ITPKB inositol-trisphosphate 3-kinase B
JUN jun proto-oncogene
JUNB jun B proto-oncogene
LEF1 lymphoid enhancer-binding factor 1
MAP7 microtubule-associated protein 7
MFSD10 major facilitator superfamily domain containing 10
NR4A1 nuclear receptor subfamily 4, group A, member 1
RAD51C RAD51 paralog C
RGS2 regulator of G-protein signaling 2
SCGB2A2 secretoglobin, family 2A, member 2
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SRGN serglycin

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AQP3 aquaporin 3 (Gill blood group)
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DCLK1 doublecortin-like kinase 1
EDNRA endothelin receptor type A
FBLN1 fibulin 1
GPX2 glutathione peroxidase 2
HOPX HOP homeobox
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
LAMA2 laminin, alpha 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MFAP4 microfibrillar-associated protein 4
MME membrane metallo-endopeptidase
NDNF neuron-derived neurotrophic factor
NFIB nuclear factor I/B
NRIP1 nuclear receptor interacting protein 1
PALLD palladin, cytoskeletal associated protein
PRDX2 peroxiredoxin 2
PTGIS prostaglandin I2 (prostacyclin) synthase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SOX11 SRY (sex determining region Y)-box 11
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TSPAN8 tetraspanin 8
XYLT1 xylosyltransferase I