BRD-K78126613_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K78126613_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ALDOC aldolase C, fructose-bisphosphate
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CCL4 chemokine (C-C motif) ligand 4
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF4A1 eukaryotic translation initiation factor 4A1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
FRY furry homolog (Drosophila)
FXYD6 FXYD domain containing ion transport regulator 6
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GLA galactosidase, alpha
GPRASP1 G protein-coupled receptor associated sorting protein 1
HES1 hes family bHLH transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT15 keratin 15, type I
KRT5 keratin 5, type II
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP1 matrix metallopeptidase 1
MSMB microseminoprotein, beta-
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OGN osteoglycin
OLFM4 olfactomedin 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PNP purine nucleoside phosphorylase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
SCPEP1 serine carboxypeptidase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
SRSF7 serine/arginine-rich splicing factor 7
SSPN sarcospan
SUSD4 sushi domain containing 4
THSD7A thrombospondin, type I, domain containing 7A
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BTBD3 BTB (POZ) domain containing 3
CALD1 caldesmon 1
CCND1 cyclin D1
CENPF centromere protein F, 350/400kDa
COL5A1 collagen, type V, alpha 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DUSP4 dual specificity phosphatase 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPRS glutamyl-prolyl-tRNA synthetase
FAM120A family with sequence similarity 120A
FOLR1 folate receptor 1 (adult)
HLTF helicase-like transcription factor
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
MAP1B microtubule-associated protein 1B
MKL2 MKL/myocardin-like 2
MLEC malectin
MTDH metadherin
NEK7 NIMA-related kinase 7
NFIB nuclear factor I/B
OSBPL8 oxysterol binding protein-like 8
PANK3 pantothenate kinase 3
PLK1 polo-like kinase 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RRP1B ribosomal RNA processing 1B
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SET SET nuclear proto-oncogene
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TMEM2 transmembrane protein 2
TMF1 TATA element modulatory factor 1
TSPAN3 tetraspanin 3
TXLNA taxilin alpha
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE3C ubiquitin protein ligase E3C
USP22 ubiquitin specific peptidase 22
WSB2 WD repeat and SOCS box containing 2