BRD-K78122587_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K78122587_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARG2 arginase 2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CALML3 calmodulin-like 3
CAST calpastatin
CCNG2 cyclin G2
CCR2 chemokine (C-C motif) receptor 2
CD46 CD46 molecule, complement regulatory protein
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLGN calmegin
CSTA cystatin A (stefin A)
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
EVI2A ecotropic viral integration site 2A
FKBP11 FK506 binding protein 11, 19 kDa
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
INSIG1 insulin induced gene 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LPIN1 lipin 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MBNL2 muscleblind-like splicing regulator 2
MKNK2 MAP kinase interacting serine/threonine kinase 2
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MYBPC2 myosin binding protein C, fast type
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEB nebulin
NELL2 NEL-like 2 (chicken)
OSBPL10 oxysterol binding protein-like 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
QPCT glutaminyl-peptide cyclotransferase
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SQLE squalene epoxidase
SST somatostatin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM45A transmembrane protein 45A
TP63 tumor protein p63
TSC22D3 TSC22 domain family, member 3
VCAN versican
WARS tryptophanyl-tRNA synthetase
WASF1 WAS protein family, member 1

decreased expression

Symbol Name
CCDC85B coiled-coil domain containing 85B
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLU clusterin
DMD dystrophin
FAM107A family with sequence similarity 107, member A
GPRC5A G protein-coupled receptor, class C, group 5, member A
MCOLN1 mucolipin 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OXTR oxytocin receptor
PFKP phosphofructokinase, platelet
PPIF peptidylprolyl isomerase F
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPTBN1 spectrin, beta, non-erythrocytic 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)