BRD-K78122587_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K78122587_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
ASNS asparagine synthetase (glutamine-hydrolyzing)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEP57 centrosomal protein 57kDa
CXCL14 chemokine (C-X-C motif) ligand 14
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
FADS1 fatty acid desaturase 1
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GNAS GNAS complex locus
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
MAP1B microtubule-associated protein 1B
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NFIL3 nuclear factor, interleukin 3 regulated
PALLD palladin, cytoskeletal associated protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNMT RNA (guanine-7-) methyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFRP4 secreted frizzled-related protein 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCF4 transcription factor 4
TRIM16 tripartite motif containing 16
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
B3GNT1
BCHE butyrylcholinesterase
CD14 CD14 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
FCN1 ficolin (collagen/fibrinogen domain containing) 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF20A kinesin family member 20A
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NTS neurotensin
PCP4 Purkinje cell protein 4
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
POSTN periostin, osteoblast specific factor
RTN2 reticulon 2
SDC2 syndecan 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
THAP11 THAP domain containing 11
TNNT1 troponin T type 1 (skeletal, slow)
TP53TG1 TP53 target 1 (non-protein coding)
TSPAN12 tetraspanin 12