BRD-K78062244_STOCK1N-27488_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K78062244_STOCK1N-27488_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CCL4 chemokine (C-C motif) ligand 4
CES1 carboxylesterase 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDR2 discoidin domain receptor tyrosine kinase 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GLUL glutamate-ammonia ligase
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
IER5 immediate early response 5
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM3A lysine (K)-specific demethylase 3A
MECOM MDS1 and EVI1 complex locus
MT1M metallothionein 1M
MUC16 mucin 16, cell surface associated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
PBX3 pre-B-cell leukemia homeobox 3
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PTN pleiotrophin
PXMP2 peroxisomal membrane protein 2, 22kDa
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SOX17 SRY (sex determining region Y)-box 17
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AMD1 adenosylmethionine decarboxylase 1
ATOX1 antioxidant 1 copper chaperone
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
CANT1 calcium activated nucleotidase 1
CCL19 chemokine (C-C motif) ligand 19
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN3 cyclin-dependent kinase inhibitor 3
CST3 cystatin C
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
GOLT1B golgi transport 1B
HAT1 histone acetyltransferase 1
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
KRT7 keratin 7, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MRPS35 mitochondrial ribosomal protein S35
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP16 NOP16 nucleolar protein
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
PYGB phosphorylase, glycogen; brain
QPCT glutaminyl-peptide cyclotransferase
RNH1 ribonuclease/angiogenin inhibitor 1
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TBC1D4 TBC1 domain family, member 4
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMX4 thioredoxin-related transmembrane protein 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB6 tubulin, beta 6 class V
URI1 URI1, prefoldin-like chaperone
VCAN versican