BRD-K78062244_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K78062244_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
CBR3 carbonyl reductase 3
CHMP1B charged multivesicular body protein 1B
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
FOSL1 FOS-like antigen 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GOLGA8A golgin A8 family, member A
GPX3 glutathione peroxidase 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IL6R interleukin 6 receptor
IQCG IQ motif containing G
IRS2 insulin receptor substrate 2
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
LMO4 LIM domain only 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PLA2G16 phospholipase A2, group XVI
PPAP2B phosphatidic acid phosphatase type 2B
SERTAD2 SERTA domain containing 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORBS2 sorbin and SH3 domain containing 2
SPRR3 small proline-rich protein 3
SRSF6 serine/arginine-rich splicing factor 6
STC2 stanniocalcin 2
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TRIM16 tripartite motif containing 16
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
AHNAK2 AHNAK nucleoprotein 2
AQP1 aquaporin 1 (Colton blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BCHE butyrylcholinesterase
BNC2 basonuclin 2
CCL4 chemokine (C-C motif) ligand 4
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CRABP2 cellular retinoic acid binding protein 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DMXL2 Dmx-like 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPN2 epsin 2
FABP7 fatty acid binding protein 7, brain
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FLRT2 fibronectin leucine rich transmembrane protein 2
GBP1 guanylate binding protein 1, interferon-inducible
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2AC histone cluster 1, H2ac
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
KCTD12 potassium channel tetramerization domain containing 12
LGALS1 lectin, galactoside-binding, soluble, 1
LRRC17 leucine rich repeat containing 17
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLN phospholamban
RFTN1 raftlin, lipid raft linker 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDC1 syndecan 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SST somatostatin
THBS1 thrombospondin 1
TRIL TLR4 interactor with leucine-rich repeats
VCAN versican