BRD-K78062244_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K78062244_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
CBR3 carbonyl reductase 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EMP1 epithelial membrane protein 1
FADS2 fatty acid desaturase 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IGF1R insulin-like growth factor 1 receptor
IL6 interleukin 6
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDSR 3-ketodihydrosphingosine reductase
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LDLR low density lipoprotein receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
MIR22HG MIR22 host gene
MSMO1 methylsterol monooxygenase 1
MX2 MX dynamin-like GTPase 2
NAMPT nicotinamide phosphoribosyltransferase
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTX3 pentraxin 3, long
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
S100A2 S100 calcium binding protein A2
SEH1L SEH1-like (S. cerevisiae)
SELE selectin E
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
THBD thrombomodulin
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADA adenosine deaminase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
CAPG capping protein (actin filament), gelsolin-like
CCND2 cyclin D2
CPA3 carboxypeptidase A3 (mast cell)
FILIP1L filamin A interacting protein 1-like
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
LGALS1 lectin, galactoside-binding, soluble, 1
MAGEA3 melanoma antigen family A3
MYB v-myb avian myeloblastosis viral oncogene homolog
NPTX2 neuronal pentraxin II
PXDN peroxidasin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
S100A8 S100 calcium binding protein A8
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SOX4 SRY (sex determining region Y)-box 4
SULF1 sulfatase 1
TPSAB1 tryptase alpha/beta 1