BRD-K78062244_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K78062244_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL4 adhesion G protein-coupled receptor L4
ADM adrenomedullin
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCL6 B-cell CLL/lymphoma 6
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA1 cyclin A1
CD38 CD38 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD93 CD93 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
FAM134B family with sequence similarity 134, member B
FLT1 fms-related tyrosine kinase 1
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
LAPTM5 lysosomal protein transmembrane 5
LRP12 low density lipoprotein receptor-related protein 12
MT1M metallothionein 1M
NEBL nebulette
NMRK1 nicotinamide riboside kinase 1
NRCAM neuronal cell adhesion molecule
NRP1 neuropilin 1
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PBX1 pre-B-cell leukemia homeobox 1
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
PXDN peroxidasin
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
SCGB1D2 secretoglobin, family 1D, member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SRGN serglycin
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF4 transcription factor 4
TMEM35 transmembrane protein 35
TMSB15A thymosin beta 15a
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNT1 troponin T type 1 (skeletal, slow)
ZFP36 ZFP36 ring finger protein
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
APOA2 apolipoprotein A-II
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CENPA centromere protein A
CTSC cathepsin C
CTSH cathepsin H
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM98A family with sequence similarity 98, member A
FUCA1 fucosidase, alpha-L- 1, tissue
GRWD1 glutamate-rich WD repeat containing 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HN1 hematological and neurological expressed 1
IER3 immediate early response 3
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGEA3 melanoma antigen family A3
MAT2A methionine adenosyltransferase II, alpha
NRIP1 nuclear receptor interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RPS11 ribosomal protein S11
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SRPX sushi-repeat containing protein, X-linked
SRSF1 serine/arginine-rich splicing factor 1
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
STK26 serine/threonine protein kinase 26
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TUBB tubulin, beta class I
UBE2S ubiquitin-conjugating enzyme E2S
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)