BRD-K78056905_MLS-0390851.0001_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K78056905_MLS-0390851.0001_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ALG8 ALG8, alpha-1,3-glucosyltransferase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CBS cystathionine-beta-synthase
CD14 CD14 molecule
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPE centromere protein E, 312kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHPT1 choline phosphotransferase 1
CKAP4 cytoskeleton-associated protein 4
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
ENO2 enolase 2 (gamma, neuronal)
FAR2 fatty acyl CoA reductase 2
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
GLRX glutaredoxin (thioltransferase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
KRT6B keratin 6B, type II
LMO4 LIM domain only 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP9 matrix metallopeptidase 9
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAMPT nicotinamide phosphoribosyltransferase
NT5DC2 5'-nucleotidase domain containing 2
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PPARD peroxisome proliferator-activated receptor delta
PYCR1 pyrroline-5-carboxylate reductase 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RXRA retinoid X receptor, alpha
S100A9 S100 calcium binding protein A9
SEPP1 selenoprotein P, plasma, 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
STC2 stanniocalcin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1
ZIC1 Zic family member 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANPEP alanyl (membrane) aminopeptidase
APOA1 apolipoprotein A-I
BMP6 bone morphogenetic protein 6
BTG2 BTG family, member 2
C1ORF116 chromosome 1 open reading frame 116
C7 complement component 7
CCL2 chemokine (C-C motif) ligand 2
CDC42 cell division cycle 42
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CYCS cytochrome c, somatic
DCN decorin
DPYSL2 dihydropyrimidinase-like 2
E2F2 E2F transcription factor 2
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FNBP1 formin binding protein 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSIG1 insulin induced gene 1
KRT19 keratin 19, type I
LEPR leptin receptor
MME membrane metallo-endopeptidase
MSLN mesothelin
MUC16 mucin 16, cell surface associated
NLRP2 NLR family, pyrin domain containing 2
NPY1R neuropeptide Y receptor Y1
OGN osteoglycin
PEG10 paternally expressed 10
PHF10 PHD finger protein 10
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
SDC4 syndecan 4
SEPT11 septin 11
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SKAP2 src kinase associated phosphoprotein 2
SPON1 spondin 1, extracellular matrix protein
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TNS1 tensin 1
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5