BRD-K77987635_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K77987635_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
AEBP1 AE binding protein 1
ANGPTL2 angiopoietin-like 2
APOD apolipoprotein D
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C10ORF10 chromosome 10 open reading frame 10
CCNE2 cyclin E2
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
DAAM1 dishevelled associated activator of morphogenesis 1
DST dystonin
EFHD1 EF-hand domain family, member D1
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP4 fatty acid binding protein 4, adipocyte
FGFR2 fibroblast growth factor receptor 2
FRY furry homolog (Drosophila)
FST follistatin
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP11 glucuronidase, beta pseudogene 11
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JCHAIN joining chain of multimeric IgA and IgM
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LAMP3 lysosomal-associated membrane protein 3
LMO3 LIM domain only 3 (rhombotin-like 2)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
METTL7A methyltransferase like 7A
MZB1 marginal zone B and B1 cell-specific protein
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAD51C RAD51 paralog C
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS5 regulator of G-protein signaling 5
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARCL1 SPARC-like 1 (hevin)
ST18 suppression of tumorigenicity 18, zinc finger
SULF1 sulfatase 1
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TMEM30B transmembrane protein 30B
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AK1 adenylate kinase 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ANXA5 annexin A5
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AQP3 aquaporin 3 (Gill blood group)
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CD151 CD151 molecule (Raph blood group)
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP10 dual specificity phosphatase 10
EMP3 epithelial membrane protein 3
FAM134B family with sequence similarity 134, member B
FKBP10 FK506 binding protein 10, 65 kDa
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
GRB14 growth factor receptor-bound protein 14
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LTBP3 latent transforming growth factor beta binding protein 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
METRN meteorin, glial cell differentiation regulator
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP98 nucleoporin 98kDa
PDLIM2 PDZ and LIM domain 2 (mystique)
PDZK1IP1 PDZK1 interacting protein 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PRR7 proline rich 7 (synaptic)
PTGES prostaglandin E synthase
RNF167 ring finger protein 167
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC44A4 solute carrier family 44, member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STEAP3 STEAP family member 3, metalloreductase
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMED3 transmembrane emp24 protein transport domain containing 3
TRAF4 TNF receptor-associated factor 4
TSKU tsukushi, small leucine rich proteoglycan
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZNF586 zinc finger protein 586